113777-20-1Relevant articles and documents
Non-steroid progesterone receptor agonist and antagonist and compounds and methods
-
, (2008/06/13)
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
Homolytic Alkylation of Enamines by Electrophilic Radicals
Russell, Glen A.,Wang, Keyang
, p. 3475 - 3479 (2007/10/02)
The electrophilic radicals R* = p-O2NC6H4CH2* or Me2C(NO2)* add readily to CH2=C(NMe)2 to yield RCH2C(NMe2)2* which undergoes electron transfer with p-O2NC6H4CH2Cl or Me2C(NO2)2 to regenerate R*.Hydrolysis yields p-O2NC6H4CH2CONMe2 and Me2C=CHC(NMe2)2(1+), respectively. p-Nitrobenzyl radicals add readily to N-pyrrolidino- or N-morpholino-1-cycloalkenes to yield after hydrolysis the α-(p-nitrobenzyl)cycloalkanones.Photostimulated alkylation of N-pyrrolidino-1-cycloalkenes by Me2C(NO2)2 is not observed although in competitive reactions between the enamine and Me2C=NO2Li, the product from attack of Me2C(NO2)* upon the eneamine double bond is formed.The N-pyrrolidino-1-cycloalkenes are more reactive toward p-O2NC6H5CH2 than their morpholine analogues.
