113823-82-8Relevant articles and documents
Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors
Lu, Xiang,Zhang, Hui,Li, Xi,Chen, Guo,Li, Qing-Shan,Luo, Yin,Ruan, Ban-Feng,Chen, Xian-Wei,Zhu, Hai-Liang
experimental part, p. 6827 - 6832 (2012/02/02)
A series of pyridine acyl sulfonamide derivatives (1-24) have been designed and synthesized and their biological activities were also evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. Among all the compounds, compound 23 displayed the most poten