113894-92-1

Basic information

• Product Name: HYDROXYPROPYL STARCH PHOSPHATE
• Synonyms: HYDROXYPROPYL STARCH PHOSPHATE;Amylopectin, phosphate, 2-hydroxypropyl ether
• CAS NO: 113894-92-1
• Molecular Formula: C10H22O6
• Molecular Weight: 238.27808
• Mol File: 113894-92-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HYDROXYPROPYL STARCH PHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROXYPROPYL STARCH PHOSPHATE(113894-92-1)
• EPA Substance Registry System: HYDROXYPROPYL STARCH PHOSPHATE(113894-92-1)

Safety Data

• Hazardous Substances Data: 113894-92-1(Hazardous Substances Data)

Usage

Description

HYDROXYPROPYL STARCH PHOSPHATE is a free-flowing white to off-white coarse powder derived from hydroxypropyl starch. It is a modified starch with added phosphate groups, which enhances its properties and makes it suitable for various applications.

Uses

Used in Pharmaceutical Industry:
HYDROXYPROPYL STARCH PHOSPHATE is used as a pharmaceutical excipient for its ability to improve the stability, solubility, and bioavailability of active pharmaceutical ingredients. Its modified structure allows for better interaction with other components in the formulation, leading to enhanced drug delivery and efficacy.
Used in Cosmetics Industry:
In the cosmetics industry, HYDROXYPROPYL STARCH PHOSPHATE is used as a thickening agent and emulsifier due to its ability to improve the texture and stability of cosmetic products. Its modified structure provides better compatibility with other ingredients, resulting in improved product performance and a more pleasant user experience.
Used in Food Industry:
HYDROXYPROPYL STARCH PHOSPHATE is used as a stabilizer, thickener, and emulsifier in the food industry. Its modified starch structure allows it to improve the texture, consistency, and shelf life of various food products, making it a valuable ingredient in the formulation of sauces, dressings, and other food items.
Used in Biomedical Applications:
HYDROXYPROPYL STARCH PHOSPHATE is used as a component in biomedical applications, such as in the development of hydrogels and scaffolds for tissue engineering. Its modified structure provides improved biocompatibility and biodegradability, making it a promising material for use in regenerative medicine and other biomedical applications.

Production Methods

Hydroxypropyl starch is produced industrially from natural starch, using propylene oxide as the modifying reagent in the presence of alkali, adding hydroxypropyl (CH(OH)CH2CH3) groups at the OH positions by an ether linkage.

Pharmaceutical Applications

Hydroxypropyl starch is a modified starch and has been used in combination with carrageenan in the production of soft capsules. Hydroxypropyl starch has been used experimentally in hydrophilic matrices, where it was shown to be an effective matrix for tablets designed for controlled-release drug delivery systems.It has also been used experimentally in the production of hydrophilic matrices by direct compression. It is used in antiseptics and is used widely in cosmetics. It is also used analytically as a bioseparation aqueous-phase-forming polymer.

Safety

Hydroxypropyl starch is widely used in cosmetics and food products. It is also used in oral pharmaceutical formulations. The WHO has set an acceptable daily intake for hydroxypropyl starch at ‘not limited’ since it was well tolerated on oral consumption. LD50 (rat, oral): 0.218 g/kg

storage

Hydroxypropyl starch is stable at high humidity and is considered to be inert under normal conditions. It is stable in emulsion systems at pH 3–9.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.