113913-36-3

Basic information

• Product Name: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide
• Synonyms: 4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID ETHYL ESTER-1,1-DIOXIDE;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID ETHYL ESTER;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID ETHYL ESTER-1,1-DIOXIDE;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ETHYL ESTER-1,1-DIOXIDE;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZE-3-CAPROXYLIC ACID-1,1-DIOXIDE ETHYL ESTER;2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID, 3,4-DIHYDRO-4-HYDROXY-2-METHYL-, ETHYL ESTER, 1,1-DIOXIDE;2-Methyl-4-Hydroxy-2H-1,2-Benzothiazine-3-Carboxylic Acid Ethyl Ester 1,1-Dioxid;4-Hydroxy-2-methyl-[2H]-1,2-benzothiazine 3-carboxylate-1,1-dioxide, ethyl ester
• CAS NO: 113913-36-3
• Molecular Formula: C12H13NO5S
• Molecular Weight: 283.3
• EINECS: 246-403-7
• Product Categories: INTERMEDIATESOFMELOXICAN;(intermediate of piroxicam)
• Mol File: 113913-36-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 140-144 °C(lit.)
• Boiling Point: 390.207 °C at 760 mmHg
• Flash Point: 189.791 °C
• Appearance: /
• Density: 1.355 g/cm³
• Vapor Pressure: 8.16E-09mmHg at 25°C
• Refractive Index: 1.617
• PKA: 12.45±0.40(Predicted)
• CAS DataBase Reference: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide(113913-36-3)
• EPA Substance Registry System: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide(113913-36-3)

Safety Data

• Hazard Codes: T
• Statements: 23
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 2
• RTECS: DL0710425
• Hazardous Substances Data: 113913-36-3(Hazardous Substances Data)

Usage

Description

2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide, also known as Piroxicam EP Impurity K, is an organic compound that serves as a crucial building block in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which includes a benzothiazine ring, a carboxylic acid group, and an ethyl ester functional group.

Uses

Used in Pharmaceutical Industry:
2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. Its incorporation into the synthesis process allows for the development of new drugs with potential therapeutic applications.
Used in Drug Development:
In the field of drug development, 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide plays a significant role as a key intermediate in the creation of novel pharmaceutical compounds. Its versatile structure enables chemists to explore various synthetic pathways, leading to the discovery of new drugs with improved efficacy and safety profiles.
Used in Medicinal Chemistry Research:
2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide is also utilized in medicinal chemistry research as a valuable tool for understanding the structure-activity relationships of various drug candidates. By studying the interactions between this compound and its derivatives with biological targets, researchers can gain insights into the design of more effective and selective therapeutic agents.

InChI:InChI=1/C12H13NO5S/c1-3-18-12(15)10-11(14)8-6-4-5-7-9(8)19(16,17)13(10)2/h4-7,14H,3H2,1-2H3