113947-56-1

Basic information

• Product Name: 6α-bromoacetoxy-4-androstene-3,17-dione
• CAS NO: 113947-56-1
• Molecular Weight: 423.347
• Mol File: 113947-56-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6α-bromoacetoxy-4-androstene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6α-bromoacetoxy-4-androstene-3,17-dione(113947-56-1)
• EPA Substance Registry System: 6α-bromoacetoxy-4-androstene-3,17-dione(113947-56-1)

Safety Data

• Hazardous Substances Data: 113947-56-1(Hazardous Substances Data)

Upstream product

• 24704-84-5 6α-hydroxy-androst-4-ene-3,17-dione 
• 598-21-0 2-Bromoacetyl bromide 

Relevant articles and documents

SYNTHESIS AND EVALUATION OF BROMOACETOXY 4-ANDROSTEN-3-ONES AS ACTIVE SITE-DIRECTED INHIBITORS OF HUMAN PLACENTAL AROMATASE

2α-Bromoacetoxy (II), 6-bromoacetoxy (VII and X), and 19-bromoacetoxy (XII) derivatives of androstenedione and 17β-bromoacetoxy compounds (III, IV, XIII-XVI) were synthesized as potential affinity-labeling reagents for aromatase. 6α-Bromoacetoxy derivative VII was the most potent inhibitor of human placental microsomal aromatase activity among this series.Its inhibitory activity was higher than that of the parent 6α-hydroxy compound V, although other bromoacetates showed weaker inhibition of aromatase than the corresponding alcohols.The bromoacetates (except the 6β-bromoacetate X) inhibited aromatase activity in a time-dependent manner in the absence of NADPH, and the enzyme inactivation was blocked by the addition of androstenedione to the incubates.Kinetic analysis of the time- and concentration-dependent inhibition by the 6β-bromo-17β-bromoacetoxy compound XV gave an apparent Ki of 25 μM and Kinact of 0.027 min-1.