113965-36-9

Basic information

• Product Name: (S)-1-((S)-1-Phenyl-ethyl)-2-propyl-piperidine
• Synonyms: (S)-1-((S)-1-Phenyl-ethyl)-2-propyl-piperidine
• CAS NO: 113965-36-9
• Molecular Weight: 231.381
• Mol File: 113965-36-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-((S)-1-Phenyl-ethyl)-2-propyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((S)-1-Phenyl-ethyl)-2-propyl-piperidine(113965-36-9)
• EPA Substance Registry System: (S)-1-((S)-1-Phenyl-ethyl)-2-propyl-piperidine(113965-36-9)

Safety Data

• Hazardous Substances Data: 113965-36-9(Hazardous Substances Data)

Upstream product

• 3074-61-1 1-propylcyclopentene 
• 7529-63-7 (1'S)-(-)-1-(1'-phenylethyl)piperidine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 912358-37-3 1-[(1S)-phenylethyl]-2-propylpiperidine-2-carbonitrile 
• 627-31-6 1,3-Diiodopropane 
• 2386-64-3 ethylmagnesium chloride 
• 178313-97-8 (S)-N-(1-phenylethyl)-2-methylideneaziridine 
• 30880-59-2 5-oxo-octanal 
• 111-24-0 1,5-dibromo-pentane 
• 912358-35-1 1-[(1S)-1-phenylethyl]piperidine-2-carbonitrile 

Downstream Products

• 555-92-0 (S)-coniine hydrochloride 
• 458-88-8 coniine 

Relevant articles and documents

Asymmetric synthesis of 2-substituted piperidines using a multi-component coupling reaction: Rapid assembly of (S)-coniine from (S)-1-(1-phenylethyl)-2-methyleneaziridine

(S)-Coniine is made using a reaction which assembles the piperidine ring by the sequential formation of four new chemical bonds and installs the C-2 stereogenic centre with high levels of diastereocontrol (90% de).

An Asymmetric Synthesis of 2-Substituted Piperidines through Ozonolysis of Cyclopentenes and Reductive Aminocyclization

By the action of ozone, sodium cyanoborohydride and the optically active benzylic amines 2, the 1-substituted cyclopentenes 1, 5 and 9 were converted to a diastereometric mixture of 1,2-disubstituted piperidines (3, 6 and 10), respectively.Hydrogenation of these compounds and the following work-up yielded optically active 2-alkylpiperidines (4, up to 68percente.e.), pipecolic acid (7, 84percent e.e.) and 2-(hydroxymethyl)piperidine (11, up to 85percente.e.).Chromatographic separation of the major isomers of 3b and 6 enabled optically pure coniine (4b) and pipecolic acid (7) to be prepared, respectively.