113976-02-6

Basic information

• Product Name: 1,3-Dioxolane, 2-(4,5-dimethoxy-2-methylphenyl)-
• CAS NO: 113976-02-6
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol File: 113976-02-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(4,5-dimethoxy-2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(4,5-dimethoxy-2-methylphenyl)-(113976-02-6)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(4,5-dimethoxy-2-methylphenyl)-(113976-02-6)

Safety Data

• Hazardous Substances Data: 113976-02-6(Hazardous Substances Data)

Upstream product

• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 103477-58-3 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane 
• 74-88-4 methyl iodide 

Downstream Products

• 113975-92-1 N,N-diethyl-4,5-dimethoxy-2-methyl-benzamide 
• 7721-62-2 4,5-dimethoxy-2-methylbenzaldehyde 

Relevant articles and documents

Synthesis and crystal structure of (4s)-4-benzyl-3-(4,5-dimethoxy-2-methylbenzoyl)- 2,2-dimethyl-1,3-oxazolidine

The synthesis of (4S)-4-benzyl-3-(4,5-dimethoxy-2-methylbenzoyl)- 2,2-dimethyl-1,3-oxazolidine 6 was performed in 7 steps starting from veratraldehyde 7. A new oxidizing system TBHP-ebselen 12 was used for oxidation of 4,5-dimethoxy-2-methylbenzaldehyde 11 into carboxylic acid 13, being the crucial step of the synthesis. The latter was transformed first to chiral amide 14 using (S)-phenylalaninol and then cyclised to oxazolidine 6. The spatial structure and the absolute configuration of the latter one was confirmed by X-ray study.