114-90-9 Usage
Description
Obidoxime Chloride, also known as Toxogonin, is an active agent primarily used as a cholinesterase reactivator. It is a white crystalline solid with potent antibacterial properties. As a reactivator, it plays a crucial role in counteracting the effects of certain nerve agents, making it a vital component in medical and military countermeasures against chemical warfare.
Uses
Used in Medical Applications:
Obidoxime Chloride is used as a cholinesterase reactivator for the treatment of poisoning caused by organophosphates and carbamates. It works by reactivating the inhibited cholinesterase enzymes, thereby reversing the toxic effects and restoring normal body functions.
Used in Military Applications:
In the context of chemical warfare, Obidoxime Chloride is used as an antidote to counteract the effects of nerve agents. Its cholinesterase reactivator properties make it an essential component in the treatment of nerve agent poisoning, providing a life-saving intervention in potential chemical attack scenarios.
Used in Pharmaceutical Industry:
Obidoxime Chloride is used as an active pharmaceutical ingredient in the development of drugs and antidotes for the treatment of poisoning caused by organophosphates and carbamates. Its incorporation into pharmaceutical products ensures the availability of effective countermeasures against these toxic substances.
Used in Antibacterial Applications:
Due to its potent antibacterial properties, Obidoxime Chloride is also used in the development of antibacterial agents. It can be incorporated into various formulations to combat bacterial infections, contributing to the fight against antibiotic-resistant strains and promoting overall public health.
Originator
Toksobidin,Polfa-Starogard
Manufacturing Process
2 Methods of producing of obidoxime chloride:
1. Into a boiling agitated solution of 2.44 g pyridine-4-aldoxime in 10 ml absolute ethanol is added dropwise during the course of 25 min a solution of 1.14 g bis-chloromethyl ether in 5 ml absolute ethanol. The reaction mixture is then refluxed for 35 min, and then agitated for 5 h at room temperature. The precipitate of bis-[4-hydroxyimino-methyl-pyridinium-(1)-methyl]-ether
Trade dichloride is thoroughly washed with absolute acetone. The yield is 3.5 g which is 98% of the theoretical, and the melting point is 229°C. If convenient, the mother liquor can be reused to make additional product.
2. 12.2 g (0.1 mole) pyridine-4-aldoxime are dissolved with heating in 125 ml chloroform. Within 25 min, 8.5 g (0.075 mole), α,α-dichlorodimethyl ether in 20 ml chloroform are dropped while stirring into the boiling solution. The reaction mixture is heated for another 35 min. After standing for several hours, the precipitate is filtered off, washed with absolute ethanol, acetone and ether and dried at 80°C. Yield: 17.0 g, 95% of the theoretical, and the melting point is 225°C (dec.).
Therapeutic Function
Antidote
Biochem/physiol Actions
Antidote for organophosphate nerve agent poisoning, but, as with other oxime agents, not full spectrum. Obidoxime fails primarily to reactivate acetylcholinesterase that has been inhibited with cyclosarin.
Safety Profile
Poison by intraperitoneal,intravenous, intramuscular, and subcutaneous routes.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of Cl- and NOx. Seealso BROMIDES.
Check Digit Verification of cas no
The CAS Registry Mumber 114-90-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 114-90:
(5*1)+(4*1)+(3*4)+(2*9)+(1*0)=39
39 % 10 = 9
So 114-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28?,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46?,47+/m0/s1
114-90-9Relevant articles and documents
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate
Cavalcante, Samir F. de A.,Kitagawa, Daniel A.S.,Rodrigues, Rafael B.,Bernardo, Leandro B.,da Silva, Thiago N.,dos Santos, Wellington V.,Correa, Ana Beatriz de A.,de Almeida, Joyce S.F.D.,Fran?a, Tanos C.C.,Ku?a, Kamil,Simas, Alessandro B.C.
, (2019/06/24)
Casualties caused by nerve agents, potent acetylcholinesterase inhibitors, have attracted attention from media recently. Poisoning with these chemicals may be fatal if not correctly addressed. Therefore, research on novel antidotes is clearly warranted. Pyridinium oximes are the only clinically available compounds, but poor penetration into the blood-brain barrier hampers efficient enzyme reactivation at the central nervous system. In searching for structural factors that may be explored in SAR studies, we synthesized and evaluated neutral aryloximes as reactivators for acetylcholinesterase inhibited by NEMP, a VX surrogate. Although few tested compounds reached comparable reactivation results with clinical standards, they may be considered as leads for further optimization.
Alkylating agents and method of use thereof
-
, (2008/06/13)
The present invention comprises a haloacetoxyalkyl ether having the formula: STR1 wherein R is H or a C1 -C4 substituted or unsubstituted alkyl group, R' is H or a C1 -C3 group, and X is chlorine or fluorine; aroyloxymethyl ethers having the formula: wherein the R is p-NO2 C6 H4, halogen substituted C6 H4, or other aromatics; the method of making such ethers and monoquaternary salts; and the method of alkylating amines, pyridines, or acetals or pyridine derivatives with such ethers to form quaternary ammonium salts; particularly HI-6, HGG-12, Toxogonin, and SAS-128.