1140322-85-5

Basic information

• Product Name: C₁₃H₁₅BrN₄O₄S₂
• CAS NO: 1140322-85-5
• Molecular Weight: 435.322
• Mol File: 1140322-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₅BrN₄O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₅BrN₄O₄S₂(1140322-85-5)
• EPA Substance Registry System: C₁₃H₁₅BrN₄O₄S₂(1140322-85-5)

Safety Data

• Hazardous Substances Data: 1140322-85-5(Hazardous Substances Data)

Upstream product

• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 
• 13178-12-6 5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine 

Downstream Products

• 1098266-19-3 C₈H₇BrN₄O₂S₂ 

Relevant articles and documents

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

A series of 2-substituted-1,3,4-thiadiazole-5-sulfamides was prepared and assayed as inhibitors of several carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic CA I and II, the membrane-associated CA IV and the mitochondrial CA VA and VB. The new compounds showed weak inhibitory activity against hCA I (KIs of 102 nM-7.42 μM), hCA II (KIs of 0.54-7.42 μM) and hCA IV (KIs of 4.32-10.05 μM) but were low nanomolar inhibitors of hCA VA and hCA VB, with inhibition constants in the range of 4.2-32 nM and 1.3-74 nM, respectively. Furthermore, the selectivity ratios for inhibiting the mitochondrial enzymes over CA II were in the range of 67.5-415, making these sulfamides the first selective CA VA/VB inhibitors.