114057-73-7Relevant articles and documents
An Intensely Sweet Dihydroflavonol Derivative Based on a Natural Product Lead Compound
Nanayakkara, N. P. Dhammika,Hussain, Raouf A.,Pezzuto, John M.,Soejarto, D. Doel,Kinghorn, A. Douglas
, p. 1250 - 1253 (2007/10/02)
The dihydroflavonol dihydroquercetin 3-acetate (1) was isolated as a sweet constituent of the young shoots of Tessaria dodoneifolia (Hook & Arn.) Cabrera (Compositae).Compound 1 and dihydroquercetin 3-acetate 4'-(methyl ether) (2), a novel synthetic analogue of this natural product lead compound, were rated by a taste panel as being 80 and 400 times sweeter than a 2percent w/v sucrose solution, respectively.Synthetic dihydroquercetin 4'-(methyl ether) (3) showed a reduced sweetness intensity when compared to 2, while (+)-dihydroquercetin (4) was devoid of sweetness.Dihydroflavonol derivatives 1-3 represent a new class of potentially noncaloric and noncariogenic intense sweeteners.