114108-84-8

Basic information

• Product Name: Diethyl(methanesulfonyloxymethyl)phosphonate, 97 %
• Synonyms: Diethyl(methanesulfonyloxymethyl)phosphonate, 97 %;Diethyl (methanesulfonyloxymethyl)phosphonate
• CAS NO: 114108-84-8
• Molecular Formula: C₆H₁₅O₆PS
• Molecular Weight: 246.22
• Mol File: 114108-84-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Diethyl(methanesulfonyloxymethyl)phosphonate, 97 %(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl(methanesulfonyloxymethyl)phosphonate, 97 %(114108-84-8)
• EPA Substance Registry System: Diethyl(methanesulfonyloxymethyl)phosphonate, 97 %(114108-84-8)

Safety Data

• Hazardous Substances Data: 114108-84-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 762-04-9 Diethyl phosphonate 
• 124-63-0 methanesulfonyl chloride 
• 3084-40-0 diethyl (1-hydroxymethyl)phosphonate 

Downstream Products

• 175408-52-3 (4-Methyl-5-phenyl-isoxazol-3-yloxymethyl)-phosphonic acid diethyl ester 
• 175408-56-7 (4-Bromomethyl-5-phenyl-isoxazol-3-yloxymethyl)-phosphonic acid diethyl ester 
• 175408-60-3 2-Acetylamino-2-[3-(diethoxy-phosphorylmethoxy)-5-phenyl-isoxazol-4-ylmethyl]-malonic acid diethyl ester 
• 180587-75-1 (R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 

Relevant articles and documents

Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents

Truncated phosphonated C-1′-branched N,O-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology, starting from N-methyl-C-(diethoxyphosphoryl)nitrone 7. Preliminary biological assays show that β-anomers are able to inhibit HIV in vitro infection at concentrations in the micromolar range. Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity.

An efficient synthesis of phosphonate derivatives of 1,2-disubstituted carbocyclic purine nucleosides with a cyclopentane ring

The synthesis of phosphonate 1,2-disubstituted carbocyclic nucleosides with a cyclopentane ring is described following two different strategies: inclusion of the phosphonomethyl group before or after coupling of the carbocyclic moiety with the heterocyclic base. The diethyl [(trifluoromethanesulfonyl)oxy] methanephosphonate is the key phosphonylating agent for both the strategies. Georg Thieme Verlag Stuttgart.

Improved Method for Preparing (R)-9-[2-(phosphonomethoxy)propyl]adenine

The present invention relates to a method for preparing high purity (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA), According to the present invention, the method uses dialkyl methylsulfonyl-oxymethyl phosphonate, which generates only a small amount of impurities in a reaction and has high purity, as an intermediate to prepare the high purity PMPA with a small amount of impurities. The present invention does not use a reagent sensitive to air and moisture contact to enhance safety and allow reproducible production and is easily handled to enable mass production. The high purity PMPA prepared by using the method can be used to prepare tenofovir disoproxil and acidic salt thereof in order to give a very favorable advantage for the production of high quality drug ingredient.COPYRIGHT KIPO 2016