114136-76-4

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-
• CAS NO: 114136-76-4
• Molecular Formula: C12H8ClF4N3O2
• Molecular Weight: 337.661
• Mol File: 114136-76-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-(114136-76-4)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-(114136-76-4)

Safety Data

• Hazardous Substances Data: 114136-76-4(Hazardous Substances Data)

Usage

Core structure

Pyrimidinedione

5-amino

A nitrogen atom with a single hydrogen atom replaced by an amino group (-NH2)

4-chloro

A chlorine atom attached to the phenyl group at the 4-position

2-fluorophenyl

A fluorine atom attached to the phenyl group at the 2-position

1-methyl

A carbon atom with three hydrogen atoms attached (-CH3) at the 1-position

trifluoromethyl

A carbon atom with three fluorine atoms attached (-CF3) at the 6-position

Potential applications

Pharmaceutical industry

Biological activities

Antiviral, antibacterial, and anticancer properties

Further research needed

To fully understand the properties and potential uses of the compound

Upstream product

• 145740-42-7 2'-Chloro-5'-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4'-fluoroacetanilide 
• 7439-89-6 iron 
• 114136-63-9 3-(4-chloro-2-fluorophenyl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 114108-90-6 ethyl N-(4-chloro-2-fluorophenyl)carbamate 
• 114136-66-2 1-methyl-6-trifluoromethyl-3-(4-chloro-2-fluorophenyl)-2,4(1H,3H)-pyrimidinedione 
• 141860-79-9 2-(dimethylamino)-4-(trifluoromethyl)-6H-1,3-oxazine-6-one 
• 372-29-2 ethyl 3-amino-4,4,4-trifluoro-2-butenoate 

Downstream Products

• 212755-16-3 3-[5-(1-trifluoromethylethylidenehydrazino)4-chloro-2-fluorophenyl]-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione 

Relevant articles and documents

Synthesis of Cyclopropyl Ester and Amide Substituted Pyrimidinediones as Protoporphyrinogen Oxidase-Inhibiting Herbicides

The protoporphyrinogen oxidase (PPO) enzyme is involved in the biosynthesis of chlorophyll and is an important target in research for development of new herbicides. In this study, new pyrimidinedione compounds with thioester tail group containing cyclopropyl moiety are synthesized from the commercially available 2-(1-(mercaptomethyl)cyclopropyl)acetic acid. The herbicidal activity of the synthesized compounds is also evaluated. Most of the synthesized compounds exhibit herbicidal activities against both monocot and dicot weeds. In particular, 10a showed similar activity to the control material, Saflufenacil. And when against the monocot weeds, Echinochloa crusgalli and Digitaria sanguinalis, 10a shows superior activity to Saflufenacil.

Discovery of N-Phenylaminomethylthioacetylpyrimidine-2,4-diones as Protoporphyrinogen IX Oxidase Inhibitors through a Reaction Intermediate Derivation Approach

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an effective target for green herbicide discovery. In this work, we reported the unexpected discovery of a novel series of N-phenylaminomethylthioacetylpyrimidine-2,4-diones (2-6) as promising PPO inhibitors

1-(3-Heterocyclylphenyl)isothiourea, -isourea, -guanidine and -amidine compounds as herbicides

There are provided 1-(3-heterocyclyphenyl)isothiourea, -isourea, -guanidine and -amidine compounds of formula I Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.