1141447-88-2

Basic information

• Product Name: 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one
• Synonyms: 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one
• CAS NO: 1141447-88-2
• Molecular Weight: 357.452
• Mol File: 1141447-88-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one(1141447-88-2)
• EPA Substance Registry System: 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one(1141447-88-2)

Safety Data

• Hazardous Substances Data: 1141447-88-2(Hazardous Substances Data)

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 22901-09-3 2-(2-bromoethyl)benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 78317-83-6 2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 98-86-2 acetophenone 

Relevant articles and documents

Visible light promoted photoredox C(sp3)-H bond functionalization of tetrahydroisoquinolines in flow

A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalizedN-aryl-substituted tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker type functionaliza

Mechanochemical Oxidative Mannich Reaction: Evaluation of Chemical and Mechanical Parameters for the Mild and Chemoselective Coupling of N-tert-butoxycarbonyltetrahydroquinolines and Ketones

A mechanochemical oxidative Mannich reaction of N-tert-butoxycarbonyl (Boc) tetrahydroquinolines and ketones was successfully developed under solvent-free ball-milling conditions. The reaction afforded the desired coupling products in satisfactory yields under mild and tractable oxidative conditions. Side reactions such as deprotection of the Boc group were prevented by carefully adjusting the milling parameters, including milling frequency, time, milling-ball filling degree, milling-ball size, and grinding auxiliary. Further examination of the scope indicated that the reaction system could also be applied to the N-benzyloxycarbonyl and N-aryl substrates to afford the corresponding products in moderate to good yields.

Visible light-induced oxidative coupling reaction: Easy access to Mannich-type products

An efficient methodology for the functionalization of sp3 C-H bond adjacent to nitrogen has been developed utilizing visible light-induced photoredox catalysis. Through optimization of solvent and light source, the reaction can be rapidly achie