114153-36-5 Usage
Description
N-(3-CHLORO-2-METHYL-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its protective group, which allows for the creation of more complex molecules in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
N-(3-CHLORO-2-METHYL-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE is used as a protected substituted aniline for the synthesis of more complex pharmaceutical compounds. Its protective group plays a crucial role in the development of advanced drugs with improved efficacy and safety profiles.
Specifically, it is used in the synthesis of Dasatinib (D193600), a potent tyrosine kinase inhibitor that targets multiple oncogenic pathways, making it an effective treatment for various types of cancer. The protective group in N-(3-CHLORO-2-METHYL-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE allows for the selective functionalization of the molecule, enabling the creation of Dasatinib with high purity and potency.
Check Digit Verification of cas no
The CAS Registry Mumber 114153-36-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,1,5 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114153-36:
(8*1)+(7*1)+(6*4)+(5*1)+(4*5)+(3*3)+(2*3)+(1*6)=85
85 % 10 = 5
So 114153-36-5 is a valid CAS Registry Number.
114153-36-5Relevant articles and documents
Twofold C-H functionalization: Palladium-catalyzed ortho arylation of anilides
Brasche, Gordon,Garcia-Fortanet, Jorge,Buchwald, Stephen L.
, p. 2207 - 2210 (2008)
(Chemical Equation Presented) The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAc)2, 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.
Substituted cinnoline derivatives as CNS depressants
-
, (2008/06/13)
The present invention comprises certain amide and ester derivatives of 4-substituted-cinnoline-3-carboxylic acids and 3-acyl-4-substituted-cinnoline derivatives, and their use as central nervous system (CNS) depressants.
