1141802-54-1

Basic information

• Product Name: N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide
• Synonyms: N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide
• CAS NO: 1141802-54-1
• Molecular Weight: 507.548
• Mol File: 1141802-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide(1141802-54-1)
• EPA Substance Registry System: N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide(1141802-54-1)

Safety Data

• Hazardous Substances Data: 1141802-54-1(Hazardous Substances Data)

Upstream product

• 52665-49-3 furan-3-sulfonyl chloride 
• 1129490-51-2 6-(4-aminophenyl)-3-(1,2-O-isopropylidene-D-ribo-tetritol-1-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

New sulphonamide and carboxamide derivatives of acyclic C-nucleosides of triazolo-thiadiazole and the thiadiazine analogues. Synthesis, anti-HIV, and antitumor activities. Part 2

A new series of acyclic C-nucleosides 1′,2′-O-isopropylidene-D- ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upon acid hydrolysis, afforded the free nucleosides 16-18. The new synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound 7 was also screened against a panel of tumor cell lines consisting of CD4 human T-cells. Copyright Taylor & Francis Group, LLC.