114190-45-3

Basic information

• Product Name: Benzoic acid, 4-methyl-2-[[(4-methylphenyl)sulfonyl]amino]-
• CAS NO: 114190-45-3
• Molecular Formula: C15H15NO4S
• Molecular Weight: 305.354
• Mol File: 114190-45-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methyl-2-[[(4-methylphenyl)sulfonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methyl-2-[[(4-methylphenyl)sulfonyl]amino]-(114190-45-3)
• EPA Substance Registry System: Benzoic acid, 4-methyl-2-[[(4-methylphenyl)sulfonyl]amino]-(114190-45-3)

Safety Data

• Hazardous Substances Data: 114190-45-3(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 2305-36-4 4-methylanthranilic acid 
• 941-55-9 4-toluenesulfonyl azide 
• 1426922-49-7 N-[2-(4'-methylbenzenesulfonamido)-4-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1570134-96-1 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-4-methyl-2-(4-methylphenylsulfonamido)benzamide 

Downstream Products

• 599-66-6 bis(4-methylphenyl) sulfone 
• 335305-93-6 2-amino-4,4'-dimethylbenzophenone 
• 81652-53-1 (2-hydroxy-4-methylphenyl)(p-tolyl)methanone 

Relevant articles and documents

Synthesis of Six- and Seven-Membered Chloromethyl-Substituted Heterocycles via Palladium-Catalyzed Amino- and Oxychlorination

The synthesis of six- and seven-membered chloromethyl-substituted heterocycles, such as piperazinone, tetrahydroquinoxaline, benzodiazepinone, and benzoxazepinone, is reported using palladium-catalyzed vicinal diheterofunctionalization of nonactivated alkenes. The reaction conditions for this domino process are soft and mild, and the chloromethyl appendage allows various post-functionalizations via simple nucleophilic substitutions.

Sulfoximine directed intermolecular o-C-H amidation of arenes with sulfonyl azides

The Ru(II)-catalyzed intermolecular o-C-H amidation of arenes in N-benzoylated sulfoximine with sulfonyl azides is demonstrated. The reaction proceeds with broad substrate scope and tolerates various functional groups. Base hydrolysis of the amidation product provides the anthranilic acid derivatives and methylphenyl sulfoximine (MPS) directing group. This method is successfully employed for the synthesis of HMR 1766.