114216-05-6Relevant articles and documents
Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives
Stitzlein, Lea M.,Stang, Christopher R. T.,Inbody, Laura R.,Rao,Schneider, Ryan A.,Dudley, Richard W.
, p. 1574 - 1579 (2019/05/28)
In the present study, a small library of bisphenol Z (BPZ) derivatives was synthesized and investigated for anti-proliferative effects in cultured breast and glioblastoma cell lines. Synthesized BPZ derivatives varied in molecular size, polarity, and lipo
Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis
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, (2008/06/13)
Compounds having the structure STR1 where m is an integer of from one to nine; n is an integer of from one to four; W is selected from substituted or unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, X is selected from C1-6 alkylene, C2-6 alkenylene and C2-6 alkynylene; Y is selected from halogen, C1-6 alkyl and C1-6, alkoxy; and Z is selected from --C(O)B; --C(R2)2 --O--N=A--C(O)B; and --C(R2)=N--O--A--C(O)B where A is C1-6 alkylene and B is --OH, --O--M+, --OD where D is a metabolically cleavable group, --OR6 where R6 is hydrogen or C1-6 alkyl, --NR6 R7 where R7 is hydrogen, C1-6 alkyl, hydroxy or C1-6 alkoxy, or where R6 and R7 taken together form a five to eight membered ring optionally containing one heteroatom selected from nitrogen, oxygen or sulfur, are inhibitors of leukotriene biosynthesis.
