1142208-21-6

Basic information

• Product Name: C₁₄H₆Cl₃N₃
• Synonyms: C₁₄H₆Cl₃N₃
• CAS NO: 1142208-21-6
• Molecular Weight: 322.581
• Mol File: 1142208-21-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: C₁₄H₆Cl₃N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₆Cl₃N₃(1142208-21-6)
• EPA Substance Registry System: C₁₄H₆Cl₃N₃(1142208-21-6)

Safety Data

• Hazardous Substances Data: 1142208-21-6(Hazardous Substances Data)

Upstream product

• 1897-45-6 chlorothalonil 
• 62-53-3 aniline 

Relevant articles and documents

USE OF SUBSTITUTED DIPHENYLAMINE COMPOUNDS IN PREPARING ANTI-TUMOUR DRUGS

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I): The groups are as defined as specification. The compound represented by formula (I) showed po

Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives

A series of polyhalo acridone heterocyclic compounds were synthesized and evaluated for their in vitro antitumor activity. It was noteworthy that halogen atoms were present at the 1, 3 and 4 sites of the compounds, and an amide group or a cyano group was at the 2 site. The antitumor bioactivity screening revealed that all the compounds exhibited potent antitumor activity. In particular, compounds 4d, 4o, 5j and 5k showed good antineoplastic selectivity, with a survival rate above 50% in NIH3T3 mouse embryonic cells. The IC50 values were 8.69-13.06 μM in A431 cells. A preliminary assessment of the structure-selectivity relationship of the compounds was also performed.

Design, synthesis, and structure-activity relationship of novel aniline derivatives of chlorothalonil

Chlorothalonil with both low cost and low toxicity is a popularly used fungicide in the agrochemical field. The presence of nucleophilic groups on this compound allows further chemical modifications to obtain novel chlorothalonil derivatives. Fluazinam, another commercially available agent with a broad fungicidal spectrum, has a scaffold of diaryl amine structure. To mimic this backbone structure, a variety of (un)substituted phenyl amines was used as nucleophilic agents to react with chlorothalonil to obtain compounds with a diphenyl amine structure. Via an elegant design, two leads, 2,4,5-trichloro-6- (2,4-dichlorophenylamino)isophthalonitrile (7) and 2,4,5-trichloro-6-(2,4,6- trichlorophenylamino)isophthalonitrile (11), with potential fungicidal activity were discovered after a preliminary bioassay screen. These two leads were further modified to obtain final products by replacing the chlorine groups in the phenyl ring in phenyl amine with other functional groups. These functional groups with various electronic properties and spatial characteristics were considered to explore the relationship between structure and fungicidal activity. The results indicate that the electron-withdrawing group NO 2 on the 4 position on the right phenyl ring plays a unique role on enhancing the fungicidal activity. The compounds were identified by proton nuclear magnetic resonance and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against cucumber downy mildew at 25 mg/L. Compound 20 has been shown as the optimal structure with 85% control against cucumber downy mildew at 6.25 mg/L concentration. The relationship between structure and fungicidal activity is reported. The present work demonstrates that chlorothalonil derivatives can be used as possible lead compounds for developing novel fungicides.