114341-71-8

Basic information

• Product Name: (4R,8R)-1-Bromo-4,8,12-trimethyltridecane
• Synonyms: (4R,8R)-1-Bromo-4,8,12-trimethyltridecane
• CAS NO: 114341-71-8
• Molecular Weight: 305.342
• Mol File: 114341-71-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (4R,8R)-1-Bromo-4,8,12-trimethyltridecane(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,8R)-1-Bromo-4,8,12-trimethyltridecane(114341-71-8)
• EPA Substance Registry System: (4R,8R)-1-Bromo-4,8,12-trimethyltridecane(114341-71-8)

Safety Data

• Hazardous Substances Data: 114341-71-8(Hazardous Substances Data)

Upstream product

• 114341-69-4 (3R,7R)-3,7,11-Trimethyldodecyl p-toluenesulfonate 
• 114341-70-7 (4R,8R)-4,8,12-Trimethyltridecanenitrile 
• 6750-34-1 (3R,7R)-hexahydrofarnesol 
• 31653-09-5 (4R,8R)-4,8,12-trimethyltridecanoic acid 
• 87247-35-6 (4R,8R)-4,8,12-trimethyltridecan-1-ol 

Downstream Products

• 143308-49-0 6-(Phenylmethoxy)-2,5,7,8-tetramethyl-4H-1-benzopyran 
• 59965-06-9 (2RS,4'R,8'R)-α-Tocopheryl benzyl ether 
• 91418-95-0 (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol 
• 18920-63-3 vitamin E 
• 59-02-9 Tocopherol 
• 14745-36-9 2-((7R,11R)-3-Hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethylbenzene-1,4-diol 
• 7559-04-8 2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione 

Relevant articles and documents

Highly stereoselective construction of the C2 stereocentre of α-tocopherol (Vitamin E) by asymmetric addition of Grignard reagents to ketones

Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77:23 dr (5 steps), 81:19 dr (5 steps) and 96:4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.

Synthesis of (2RS,4'R,8'R)-α-tocopherol and related compounds via a 2-chlorochroman

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2-allylchromans

Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.