114360-62-2

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(di-4-morpholinylphosphinite)
• CAS NO: 114360-62-2
• Molecular Formula: C39H47N4O9P
• Molecular Weight: 746.797
• Mol File: 114360-62-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(di-4-morpholinylphosphinite)(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(di-4-morpholinylphosphinite)(114360-62-2)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(di-4-morpholinylphosphinite)(114360-62-2)

Safety Data

• Hazardous Substances Data: 114360-62-2(Hazardous Substances Data)

Upstream product

• 75302-66-8 dimorpholinophosphinous chloride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 5815-61-2 tris(morpholino)phosphine 

Downstream Products

• 114388-18-0 dithymidyl(3',5')phosphoromorpholidite 

Relevant articles and documents

A simple Preparation of 5'-O-dimethoxytrityl Deoxyribonucleoside 3'-O-Phosphorbisdiethylamidites as Useful Intermediates in the Synthesis of Oligodeoxyribonucleotides and Their Phosphorodiethylamidate Analogs on a Solid Support

5'-O-Dimethoxytrityl deoxyribonucleoside 3'-O-phosphorbisdiethylamidites were prepared by the selective phosphitylation of 5'-O-dimethoxytrityl deoxyribonucleosides with tris(diethylamino)phosphine in the presence of amine and tetrazol as catalyst.The bisamidites activated by p-nitrophenyltetrazole can be coupled efficiently with 5'hydroxyl group of nucleoside on a solid support.Oligodeoxyribonucleotides were obtined in high yields.The phosphorodiethylamidate linkage was obtained by non-aqueous oxidation using tert-butyl hydroperoxyde of the phosphordiethylamidite formed after the coupling.