114370-98-8

Basic information

• Product Name: 5-[(2-hydroxyphenyl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• Synonyms: 4,6(1H,5H)-pyrimidinedione, dihydro-5-[(2-hydroxyphenyl)methylene]-2-thioxo-
• CAS NO: 114370-98-8
• Molecular Formula: C₁₁H₈N₂O₃S
• Molecular Weight: 248.2578
• Mol File: 114370-98-8.mol
• Article Data: 12

Chemical Properties

• Density: 1.56g/cm³
• Refractive Index: 1.736
• CAS DataBase Reference: 5-[(2-hydroxyphenyl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2-hydroxyphenyl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(114370-98-8)
• EPA Substance Registry System: 5-[(2-hydroxyphenyl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(114370-98-8)

Safety Data

• Hazardous Substances Data: 114370-98-8(Hazardous Substances Data)

Upstream product

• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 27430-16-6 5,5'-(Salicylidene)bis-(2-thiobarbituric acid) 

Relevant articles and documents

Complexing properties of some pyrimidines

The synthesis of transition metal barbiturate, and thiobarbiturate complexes containing different functional groups of variable electronic character with CoII, NiII, CuII, Pd II, and PtII have been pr

Composition for trichogenousness

The present invention relates to novel barbiturate and thiobarbiturate derivatives and a composition for promoting hair growth using the same. According to the present invention, the barbiturate and thiobarbiturate derivatives, in an animal model, have shown to promote hair growth and have excellent effects on hair growth by promoting regulation of Wnt/andbeta;-catenin and hair growth factor signaling and suppressing mechanism of apoptosis. Accordingly, the barbiturate and thiobarbiturate derivatives of the present invention may be used as a composition for promoting hair growth.COPYRIGHT KIPO 2017

Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors

Here a new class of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates were designed, synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that several compounds had more potent tyrosinase inhibitory activities than the widely used tyrosinase inhibitor kojic acid (IC50 = 18.25 μM). In particular, 3′,4′-dihydroxylated 1e was found to be the most potent inhibitor with IC50 value of 1.52 μM. The inhibition mechanism analysis revealed that the potential compounds 1e and 2e exhibited such inhibitory effects on tyrosinase by acting as the irreversible inhibitors. Structure-activity relationships' (SARs) analysis also suggested that further development of such compounds might be of interest.

Synthesis, theoretical investigation of 5-(4-dimethylaminobenzylidene) thiobarbituric acid

In this study, synthesis of 5-benzylidene thiobarbituric acid derivative has been described. The route of preparation involved the uses of thiobarbituric acid as starting material and treated with 4-dimethylaminobenzaldehyde compound to give required derivative. This compound was identified by spectroscopic methods; H NMR, FTIR and CHNS analysis and also by measuring its melting point. A theoretical investigation is performed using hybrid Beck model (B3LYP), ESP showed regular distribution of charge density of whole molecule when one of the two proton is removed from ?-carbon, the ESP for HOMO electron density is heavily localized on α negative carbon, reflect the reactivity of thiobarbituric molecule and show it as highly effective nucleophile when act into nucleophilic substitution reactions.