114377-40-1

Basic information

• Product Name: 1-(benzyloxy)-2-Methylpropan-2-aMine
• Synonyms: 1-(benzyloxy)-2-Methylpropan-2-aMine;2-Benzyloxy-1,1-dimethyl-ethylamine
• CAS NO: 114377-40-1
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.25878
• Mol File: 114377-40-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(benzyloxy)-2-Methylpropan-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-2-Methylpropan-2-aMine(114377-40-1)
• EPA Substance Registry System: 1-(benzyloxy)-2-Methylpropan-2-aMine(114377-40-1)

Safety Data

• Hazardous Substances Data: 114377-40-1(Hazardous Substances Data)

Usage

Chemical class

Amines

Derivative of

Amphetamines

Common use

Precursor in the synthesis of pharmaceutical drugs (amphetamines and psychoactive substances)

Application

Medicinal chemistry for drug development

Form

Typically used as hydrochloride salt

Properties

Stimulant and psychoactive

Importance

Significant in pharmacology and drug discovery

Upstream product

• 75-16-1 methylmagnesium bromide 
• 100-44-7 benzyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 390407-64-4 3-(2-benzyloxy-1,1-dimethyl-ethyl)-2-chloro-[1,3,2]oxazaphosphinane 2-oxide 
• 136888-69-2 (1-benzyloxy-2-methyl)prop-2-ylisocyanate 

Relevant articles and documents

NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS

The present invention covers substituted Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Synthesis, in vitro metabolic studies, and antitumour activity of methyl analogues of ifosfamide

Synthesis of 2-chloro-1,1-dimethylethyl and 2-chloro-2,2-dimethylethyl analogues of ifosfamide was performed via aziridine intermediate. In vitro metabolic activation showed that both compounds are metabolised at a rate similar to the parent drug. However, their anticancer activity against L1210 leukaemia in mice was lower as compared with ifosfamide. The reduction of antitumour efficiency of examined analogues is probably caused by a lower ability to cross-link DNA by their final, active metabolites.

Azaoxindole derivatives

This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.