114379-92-9 Usage
Description
1-(4-(methyl-d3)phenyl)ethan-1-one, also known as 4''-Methyl-d3-acetophenone, is a deuterated compound derived from 4''-Methylacetophenone. It is characterized by the presence of a methyl group and a deuterium atom attached to the phenyl ring, which distinguishes it from its non-deuterated counterpart. This unique feature makes it a valuable compound for various applications, particularly in the fields of research and development.
Uses
Used in Pharmaceutical Industry:
1-(4-(methyl-d3)phenyl)ethan-1-one is used as a key intermediate in the preparation of crystalline forms of substituted Imidazopyrazinecarboxamides. These compounds serve as Phosphoinositide 3-kinase (PI3K) inhibitors, which play a crucial role in the regulation of cellular processes such as cell growth, survival, and metabolism. The deuterated version of this compound is particularly useful in the development of more effective and targeted therapies for various diseases, including cancer.
Used in Cosmetics and Perfumery Industry:
1-(4-(methyl-d3)phenyl)ethan-1-one is used as a methylated acetophenone in cosmetics and perfumery. Its unique scent profile and stability make it a valuable ingredient in the formulation of fragrances and other cosmetic products. The presence of the deuterium atom in this compound may also provide additional benefits, such as enhanced stability and longevity of the fragrance.
Used in Polymer Industry:
1-(4-(methyl-d3)phenyl)ethan-1-one is used as a catalyst in the photopolymerization of Methyl methacrylate. The presence of the 4''-Methylacetophenone has been shown to accelerate the photopolymerization process, leading to faster curing times and improved material properties. This makes it a valuable component in the production of various polymer-based materials, such as coatings, adhesives, and plastics.
Check Digit Verification of cas no
The CAS Registry Mumber 114379-92-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,3,7 and 9 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114379-92:
(8*1)+(7*1)+(6*4)+(5*3)+(4*7)+(3*9)+(2*9)+(1*2)=129
129 % 10 = 9
So 114379-92-9 is a valid CAS Registry Number.
114379-92-9Relevant articles and documents
CRYSTALLINE FORMS OF A PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITOR
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Paragraph 0258-0260, (2020/03/23)
The present invention relates to salts and crystalline forms of 2-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl)-4-methylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide, crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, and crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-(methyl-d3)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, which are PI3K inhibitors useful in the treatment of cancer and other diseases.
Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate
Komeyama, Kimihiro,Yamahata, Yuta,Osaka, Itaru
supporting information, p. 4375 - 4378 (2018/07/29)
Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide r
