114390-40-8Relevant articles and documents
Stability of bromhexine and the structure of its degradation products
Goeber, B.,Lisowski, Hannelore,Franke, P.
, p. 23 - 26 (2007/10/02)
Refluxed acid or neutral aqueous solutions of Bromhexine (1) show four degradation products. 1 is decomposed at room temperature (20 deg C; 1 year) 1percent.Degradation products of crystalline 1 are not detectable in the temperature-moisture-test.Under normal storage conditions a 5-year stability for aqueuos solutions and a more than 10-year stability for crystalline 1 are estimated.Very small amounts of three degradation products were isolated by TLC.According to MS-, UV- and IR-analysis their structures are 3-cyclohexyl-6,8-dibromo-chinazoline-4-one (2a), 3-cyclohexyl-6,8-dibromo-chinazoline (2b) and 3-amino-4,6-dibromo-benzaldehyde (3).The structure of N-Methylcyclohexylamine is supposed for a further product.MS fragmentation and degradation mechanisms are discussed.