114395-16-3Relevant articles and documents
Synthesis of Tetrahydroquinoline-Embedded Bridged Benzothiaoxazepine-1,1-dioxides
Borgohain, Hemi,Devi, Runjun,Dheer, Divya,Borah, Biraj Jyoti,Shankar, Ravi,Das, Sajal Kumar
supporting information, p. 6671 - 6679 (2017/12/07)
A diastereoselective synthesis of previously unknown tetrahydroquinoline-containing bridged benzothiaoxazepine-1,1-dioxides is presented. The three-step protocol uses readily available N-aryl-2-fluorobenzenesulfonamides and trans-2,3-epoxy-cinnamyl-alcohol-derived tosylates as the starting materials, involves N-alkylation of sulfonamides, intramolecular epoxide ring-opening, and SNAr reactions as the reaction steps, and requires only one chromatographic purification to access the desired products in good overall yields.
An alternate synthesis of appetite suppressant (R)-2-benzylmorpholine employing Sharpless asymmetric epoxidation strategy
Viswanadh,Mujumdar,Sasikumar,Kunte,Muthukrishnan
, p. 861 - 863 (2016/02/05)
An alternate synthesis of (R)-2-benzylmorpholine 1, an appetite suppressant agent has been accomplished starting from readily available trans-cinnamyl alcohol employing Sharpless asymmetric epoxidation strategy as a key step, with an overall yield of 24%.
Rearrangement Reactions of Epoxides in the Presence of 2-Mercaptopyridine N-Oxide Sodium Salt.
Lampard, Christopher,Murphy, John A.,Lewis, Norman
, p. 3841 - 3848 (2007/10/02)
Reaction of glycidyl bromides and tosylates with sodium salt of mercaptopyridine N-oxide led to the formation of episulphides.
