114402-22-1

Basic information

• Product Name: [(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID
• Synonyms: [(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID;[(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)THIO]ACETIC ACID;ALINDA 101514;UKRORGSYN-BB BBV-200818
• CAS NO: 114402-22-1
• Molecular Formula: C₁₀H₁₀N₄O₂S
• Molecular Weight: 250.28
• Mol File: 114402-22-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 183-184 °C
• Boiling Point: 554.0±52.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 3.04±0.10(Predicted)
• CAS DataBase Reference: [(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID(114402-22-1)
• EPA Substance Registry System: [(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID(114402-22-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 114402-22-1(Hazardous Substances Data)

Usage

General Description

[(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)SULFANYL]ACETIC ACID is a chemical compound that belongs to the class of organic compounds known as phenyltriazoles. It is a sulfa drug derivative used as an antibacterial agent. The compound has a triazole ring, which is a five-membered heterocyclic ring containing three nitrogen atoms and two adjacent carbon atoms. It also contains an amino group, a phenyl ring, and a sulfanyl group attached to an acetic acid moiety. The compound's molecular structure makes it a potential candidate for therapeutic agents in the treatment of various bacterial infections.

Upstream product

• 22706-11-2 4-amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione 
• 169304-24-9 ethyl 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetate 
• 111828-07-0 (4-Amino-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid methyl ester 
• 111828-01-4 (4-amino-5-phenyl-4H-1,2,4-triazol-3-ylsulphanyl)-methylenenitrile 
• 6178-44-5 ethyl 3,4,5-trimethoxybenzoate 
• 3291-03-0 3,4,5-trimethoxybenzohydrazide 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 31821-78-0 3-(3,4,5-trimetossifenil)-4-ammino-5-mercapto-4H-1,2,4-triazolo 
• 7449-45-8 methyl N'-benzoylhydrazinocarbodithioate 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

Synthesis and biological activity test of some new five membered heterocycles

A new series of 1,3,4-oxadiazoles, 1,2,4-triazoles, 1,3,4-thiadiazoles were synthesized using alkylhydrazides as the starting materials, and then 1,2,4-triazoles were used to synthesize [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. All the compounds were evaluated for in vitro antibacterial activity and antitumor activity. A new series of five membered heterocyclic compounds were synthesized using alkylhydrazides as the starting materials. All the compounds were evaluated for in vitro antibacterial activity and antitumor activity.

STUDIES ON 4-AMINO-5-ARYL-1,2,4-TRIAZOLE-3-THIONES

4-Amino-5-aryl-1,2,4-triazole-3-thiones 1 react with phenacylbromide at room temperature to give 2, which could be converted to 3 on reflux. Treatment of 1 with chloroacetonitrile and potassium hydroxide in equimolar ratio and in excess yielded 4 and 6, r