114454-97-6

Basic information

• Product Name: <(1R,2R,3S,5R)-3-hydroxy-5-methyl-2-nitrocyclohexyl>-pivalat
• Synonyms: <(1R,2R,3S,5R)-3-hydroxy-5-methyl-2-nitrocyclohexyl>-pivalat
• CAS NO: 114454-97-6
• Molecular Weight: 259.302
• Mol File: 114454-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <(1R,2R,3S,5R)-3-hydroxy-5-methyl-2-nitrocyclohexyl>-pivalat(CAS DataBase Reference)
• NIST Chemistry Reference: <(1R,2R,3S,5R)-3-hydroxy-5-methyl-2-nitrocyclohexyl>-pivalat(114454-97-6)
• EPA Substance Registry System: <(1R,2R,3S,5R)-3-hydroxy-5-methyl-2-nitrocyclohexyl>-pivalat(114454-97-6)

Safety Data

• Hazardous Substances Data: 114454-97-6(Hazardous Substances Data)

Upstream product

• 6280-15-5 3-methylpentanedial 
• 114472-85-4 <(1R,2R,3S,5R)-3-acetoxy-5-methyl-2-nitrocyclohexyl>-pivalat 

Relevant articles and documents

Enantioselective Saponification of Diacetates of 2-Nitro-1,3-propanediols by Pig-Liver Esterase and Preparation of Enantiomerically Pure Derivatives of 2-Nitro-allylic Alcohols (Chiral Multiple-Coupling Reagents)

The reproducible enantioselective saponification of open-chain and cyclic diacetates of meso-2-nitro-1,3-propanediols (see 4b-13b) with pig-liver esterase (PLE) gives monoacetates (see 4c-13c) of >95percent enantiomeric excess.The Re enantiotopic acetate group appears to be saponified preferentially, as proved by the X-ray crystal structure analysis of three camphanoates 4d, 6d, and 7d.Elimination of H2O or AcOH from the hydroxy acetates thus available gives derivatives of nitro-allylic alcohols (see 20-24, 27, and 29) which are subjected to diastereoselective Michael additions or SN2' substitutions.