1145660-04-3

Basic information

• Product Name: (E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine
• Synonyms: (E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine
• CAS NO: 1145660-04-3
• Molecular Weight: 270.641
• Mol File: 1145660-04-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine(1145660-04-3)
• EPA Substance Registry System: (E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine(1145660-04-3)

Safety Data

• Hazardous Substances Data: 1145660-04-3(Hazardous Substances Data)

Upstream product

• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 58551-83-0 2,4,6-trifluorobenzaldehyde 

Downstream Products

• 1145660-05-4 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine 
• 1146767-50-1 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine 

Relevant articles and documents

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases

Alzheimer's disease (AD) is a complex, multifactorial disease in which different neuropathological mechanisms are likely involved, including those associated with pathological tau and Aβ species as well as neuroinflammation. In this context, the development of single multitargeted therapeutics directed against two or more disease mechanisms could be advantageous. Starting from a series of 1,5-diarylimidazoles with microtubule (MT)-stabilizing activity and structural similarities with known NSAIDs, we conducted structure-Activity relationship studies that led to the identification of multitargeted prototypes with activities as MT-stabilizing agents and/or inhibitors of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways. Several examples are brain-penetrant and exhibit balanced multitargeted in vitro activity in the low μM range. As brain-penetrant MT-stabilizing agents have proven effective against tau-mediated neurodegeneration in animal models, and because COX-and 5-LOX-derived eicosanoids are thought to contribute to Aβ plaque deposition, these 1,5-diarylimidazoles provide tools to explore novel multitargeted strategies for AD and other neurodegenerative diseases.

NOVEL IMIDAZOLE DERIVATIVES

The present invention relates to novel imidazole derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is halogen, C1-C4alkyl or C1-Cs