1145998-81-7

Basic information

• Product Name: Kisspeptin 234
• Synonyms: Kisspeptin 234
• CAS NO: 1145998-81-7
• Molecular Formula: C63H78N18O13
• Molecular Weight: 1295.40622
• Mol File: 1145998-81-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: insoluble in DMSO; insoluble in EtOH; ≥4.44 mg/mL in H2O with ultrasonic
• CAS DataBase Reference: Kisspeptin 234(CAS DataBase Reference)
• NIST Chemistry Reference: Kisspeptin 234(1145998-81-7)
• EPA Substance Registry System: Kisspeptin 234(1145998-81-7)

Safety Data

• Hazardous Substances Data: 1145998-81-7(Hazardous Substances Data)

Usage

Biological Activity

kisspeptin 234 is a kisspeptin receptor antagonist, with the ability to antagonize kisspeptin-10-induced activation of gpr-54. kisspeptin binds to its cognate receptor (i.e. gpr-54) on neurons that produce gonadotropin-releasing hormone (gnrh), and stimulates their activity, which in turn sends an obligatory signal for gnrh secretion, thereby gating down-stream events supporting reproduction. the development of kisspeptin receptor antagonists may provide a valuable tool for exploring the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction, and could serve as a potential therapeutic agent for treating hormone-dependent disorders of reproduction, such as precocious puberty, endometriosis, as well as metastatic prostate cancer.1. roseweir ak, kauffman as, smith jt, et al. discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. journal of neuroscience, 2009, 29(12): 3920-3929.