1146217-01-7

Basic information

• Product Name: C₁₅H₁₁Cl₃N₄O₂
• CAS NO: 1146217-01-7
• Molecular Weight: 385.637
• Mol File: 1146217-01-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₁Cl₃N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₁Cl₃N₄O₂(1146217-01-7)
• EPA Substance Registry System: C₁₅H₁₁Cl₃N₄O₂(1146217-01-7)

Safety Data

• Hazardous Substances Data: 1146217-01-7(Hazardous Substances Data)

Upstream product

• 1897-45-6 chlorothalonil 
• 21418-71-3 ethyl 2-(imidazolidin-2-ylidene)acetate 

Relevant articles and documents

Solvent-free, microwave assisted synthesis of polyhalo heterocyclic ketene aminals as novel anti-cancer agents

A series of polyhalo heterocyclic ketene aminals (polyhalo-HKAs) were synthesized under solvent-free conditions and evaluated in vitro against a panel of human tumor cell lines. Trifluoro-HKAs were the most cytotoxic compounds, followed by difluoro-HKAs and trichloro-HKAs. Trichloro-HKAs were more potent against the tumor cell lines Skov-3, Hep-2, K562, and A431 than difluoro-HKAs. An ethoxycarbonyl at the 2-position of the polyhalo HKAs gave the highest activity. Ethoxycarbonyl substituted 5o, bearing three fluorine atoms on the isophthalonitrile ring, was found to be the most potent derivative with IC50 values lower than 3.7 μg/mL against five human tumor cell lines making it more active than cisplatin (DDP).