1146221-86-4

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-diMethylethyl)-4-(trifluoroMethyl)-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-diMethylethyl)-4-(trifluoroMethyl)-
• CAS NO: 1146221-86-4
• Molecular Formula: C13H12F3N3
• Molecular Weight: 267.2496896
• Mol File: 1146221-86-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-diMethylethyl)-4-(trifluoroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-diMethylethyl)-4-(trifluoroMethyl)-(1146221-86-4)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(1,1-diMethylethyl)-4-(trifluoroMethyl)-(1146221-86-4)

Safety Data

• Hazardous Substances Data: 1146221-86-4(Hazardous Substances Data)

Usage

Structure

Pyrrolopyridine derivative with a carbonitrile group attached to the 3-position of the pyrrolopyridine ring

Substituents

A tert-butyl group at the 1-position and a trifluoromethyl group at the 4-position

Potential applications

Pharmaceutical research and development, particularly in the discovery of new drugs for various therapeutic indications

Value

Unique structure and chemical properties make it a potentially valuable building block for the synthesis of novel drug candidates with enhanced pharmacological properties.

Upstream product

• 1146221-85-3 (E)-1-tert-butyl-5-[(4,4,4-trifluoro-3-oxobut-1-enyl)amino]-1H-pyrrole-3-carbonitrile 

Downstream Products

• 1092579-96-8 4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Facile synthesis of fluorinated pyrrolo[2,3-b]pyridines

With the purpose to synthesize novel ADAs (adenosine deaminase) and IMPDH (inosine 5′-monophosphate dehydrogenase) inhibitors the reaction of 5-amino-1-tert-butyl-1H-pyrrolo-3-carbonitrile with fluorinated 1,3-biselectrophiles was studied. An efficient an