114646-77-4

Basic information

• Product Name: Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)-
• CAS NO: 114646-77-4
• Molecular Formula: C20H20O2
• Molecular Weight: 292.378
• Mol File: 114646-77-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)-(114646-77-4)
• EPA Substance Registry System: Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)-(114646-77-4)

Safety Data

• Hazardous Substances Data: 114646-77-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)- is a chemical compound that belongs to the class of ketones. It is a derivative of 2,5-diphenyl-2H-pyran with a methyl group attached at the 6 position and a ketone functional group at the 1 position. Ethanone, 1-(3,4-dihydro-6-methyl-2,5-diphenyl-2H-pyran-2-yl)- exhibits various pharmacological activities and has been studied for its potential therapeutic applications. It may possess antioxidant, antimicrobial, or anti-inflammatory properties, however further research is needed to fully understand its biological effects and potential uses.

Upstream product

• 32123-84-5 3-phenylbut-3-en-2-one 
• 50-00-0 formaldehyd 
• 103-79-7 1-phenyl-acetone 
• 1198-01-2 Me₃SnCPhCH₂ 
• 75-36-5 acetyl chloride 
• 141-97-9 ethyl acetoacetate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 31034-99-8 4-dimethylamino-3-phenyl-2-butanone methiodide 
• 77197-64-9 1.methyl-2-phenylcyclopropene 
• 178425-56-4 1,1,2-tribromo-2-phenylcyclopropane 

Relevant articles and documents

Ene di- and trimerization of 1-methyl-2-phenylcyclopropene

1,2-Disubstituted cyclopropene, 1-methyl-2-phenylcyclopropene (18), was generated by bromo-lithium exchange of 1-bromo-2-phenylcyclopropene followed by treatment with methyl iodide. Compound 18 was oxidized by oxygen to give the α,β-unsaturated carbonyl product 25 and diketone 27 and the tautomeric, β-hydroxyl-α,β-unsaturated ketone 28. However, compound 28 reacted further with the cyclopropene 18 in a retro-Claisen-like reaction to generate adduct 26. Furthermore, compound 18 underwent ene dimerization in neat condition to form the endo-dimer 40 and exo-dimer 41 followed by oxidization with oxygen to give aldehyde 39. It is noteworthy that the endo-dimer 40 and exo-dimer 41 could be trapped with thiophenol to give adduct 42 and 43. In addition, the ene reaction of exo-dimer 41 with monomer 18 gave an exo-exo ene trimer 46 through an exo-transition state which was also trapped by thiophenol to give adducts 44 and 45.

Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide

Birch reduction-alkylation of the chiral 2-(trimethylsilyl)benzamide 4 provides 1,4-cyclohexadienes 5b-5e with diastereomer ratios of >100:1. The conversions of 5b-5e to the 4,4-disubstituted-2-cyclohexen-1-ones 8b-8e are described.