1146629-01-7

Basic information

• Product Name: 3-benzoyl-5-methyl-1-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 3-benzoyl-5-methyl-1-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1146629-01-7
• Molecular Weight: 540.529
• Mol File: 1146629-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzoyl-5-methyl-1-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoyl-5-methyl-1-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione(1146629-01-7)
• EPA Substance Registry System: 3-benzoyl-5-methyl-1-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)pyrimidine-2,4(1H,3H)-dione(1146629-01-7)

Safety Data

• Hazardous Substances Data: 1146629-01-7(Hazardous Substances Data)

Upstream product

• 60699-01-6 6-(bromomethyl)-1,3,8-trimethoxyanthracene-9,10-dione 
• 4330-20-5 N-3-benzoylthymine 

Relevant articles and documents

ω,ω′-Appended nucleo-base derivatives of hypericin

ω,ω′-Disubstituted hypericin derivatives with the nucleo-bases thymine, cytosine, and adenine in these positions were prepared starting from tri-O-methyl-ω-bromoemodin. The most promising derivative proved to be that with a thymine moiety. It displayed the best solubility of the three products together with a potency to produce singlet oxygen and/or reactive oxygen species comparable to the parent compound hypericin. In addition, although no specific interaction with DNA or poly(2′- deoxyadenylic acid) could be detected, it proved to be significantly better accumulating in the nucleus of prostatic cancer LNCaP cells than hypericin making it a promising candidate for a second-generation photodynamic hypericin agent.