114684-99-0

Basic information

• Product Name: 2-[(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino]ethanol
• CAS NO: 114684-99-0
• Molecular Formula: C₈H₉ClN₄O
• Molecular Weight: 212.6363
• Mol File: 114684-99-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 448.8°C at 760 mmHg
• Flash Point: 225.2°C
• Density: 1.589g/cm³
• Vapor Pressure: 7.73E-09mmHg at 25°C
• Refractive Index: 1.766
• CAS DataBase Reference: 2-[(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino]ethanol(114684-99-0)
• EPA Substance Registry System: 2-[(2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino]ethanol(114684-99-0)

Safety Data

• Hazardous Substances Data: 114684-99-0(Hazardous Substances Data)

Upstream product

• 141-43-5 ethanolamine 
• 63200-54-4 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine 
• 16632-21-6 5-nitro-6-methyluracil 
• 65996-50-1 2,4-Dioxo-1,2,3,4-tetrahydropyrrolo<3,2-d>pyrimidine 
• 114684-93-4 4-Chloro-2-oxo-1,2-dihydropyrrolo<3,2-d>pyrimidine 
• 116705-41-0 5-Nitro-2,4-dioxo-6-(β-dimethylaminovinyl)-1,2,3,4-tetrahydropyrimidine 

Relevant articles and documents

A facile synthesis of 9-deaza analogue of olomoucine

Heating of 6-(benzylamino)-2-chloro-9-deazapurine (3) with ethanolamine afforded 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-deazapurine (8). Its treatment with formaldehyde in alkaline solution, after protection of the OH group with DMTr, led to hydroxymethylation at position 9. Conversion of the hydroxymethyl group to methyl was performed by catalytic hydrogenation under simultaneous deprotection, which resulted in the formation of the 9-deaza analogue 1 of olomoucine. Compound 1 does not exhibit any significant in vitro cell growth inhibition of CCRF-CEM, HeLa and L-1210 cell lines. Cytostatic activity was found in 6-(benzylamino)-9-deazapurine (2) and its 2-chloro derivative 3 in CCRF-CEM cells with IC50 13.3 and 15:8 μM, respectively.