114688-66-3

Basic information

• Product Name: 2-(4-chloro-2-nitrobenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-(4-chloro-2-nitrobenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 114688-66-3
• Molecular Weight: 332.787
• Mol File: 114688-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-2-nitrobenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-2-nitrobenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(114688-66-3)
• EPA Substance Registry System: 2-(4-chloro-2-nitrobenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(114688-66-3)

Safety Data

• Hazardous Substances Data: 114688-66-3(Hazardous Substances Data)

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 52311-59-8 4-chloro-2-nitrobenzyl bromide 

Relevant articles and documents

2-(aminobenzyl)-1,2,3,4-tetrahydroisoquinolines: A new class of α2-adrenergic receptor antagonists

A new class of α2-adrenergic receptor antagonists, the 2-(aminobenzyl)-1,2,3,4-tetrahydroisoquinolines 4 and their derivatives, is described. Two synthetic routes are reported. An investigation of the structure-activity relationships including various substitutions of the isoquinoline moiety and the benzyl group is discussed. The affinity and selectivity for both α1- and α2-adrenoceptors was defined by studying the displacement of [3H]-prazosin (α1-sites) and [3H]-yohimbine (α2-sites) from rat brain membranes. The 2-(2-amino-3,4-dimethoxybenzyl)-6-methoxy-1,2,3,4- tetrahydroisoquinoline 4a presented affinity and selectivity close to yohimbine. In functional experiments the α-adrenoceptor blocking properties of 4a have been evaluated on isolated rat aorta and on the twitch responses of the isolated rat vas deferens.