1147-56-4 Usage
Description
1-(2-Thiazolylazo)-2-naphthol, also known as ERGi-USU, is a high affinity Rio Kinase 2 (RIOK2) inhibitor with a dissociation constant (Kd) of 200 nM. It selectively inhibits the growth of ERG-positive cancer cells, such as VCaP prostate cancer, COLO320 colon cancer, KG-1, and MOLT-4 leukemia cells, with minimal effect on ERG-negative cells or normal cells. 1-(2-Thiazolylazo)-2-naphthol also disrupts ribosomal biogenesis and causes ribosomal stress by selectively inhibiting the kinase RIOK2.
Uses
Used in Cancer Treatment:
1-(2-Thiazolylazo)-2-naphthol is used as a targeted therapy for ERG-positive cancer cells, including prostate, colon, and leukemia cancers. Its application is based on its ability to selectively inhibit the growth of these cancer cells with minimal effect on normal cells or ERG-negative cell lines. This selective inhibition is due to its high affinity for the Rio Kinase 2 (RIOK2), which plays a role in the growth and survival of ERG-positive cancer cells.
Used in Drug Development:
1-(2-Thiazolylazo)-2-naphthol is used as a lead compound in the development of new drugs targeting ERG-positive cancers. Its high selectivity and potency make it a promising candidate for further research and development, potentially leading to more effective treatments for patients with these types of cancers.
Used in Research:
1-(2-Thiazolylazo)-2-naphthol is used as a research tool to study the role of ERG and RIOK2 in cancer cell growth and survival. By understanding the mechanisms of action of this compound, researchers can gain insights into the biology of ERG-positive cancers and identify potential therapeutic targets for future drug development.
Used in Drug Screening:
1-(2-Thiazolylazo)-2-naphthol can be used in high-throughput screening assays to identify other compounds with similar properties and potential applications in cancer treatment. This can help in the discovery of new drugs with improved selectivity, potency, and reduced side effects for patients with ERG-positive cancers.
References
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
Check Digit Verification of cas no
The CAS Registry Mumber 1147-56-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1147-56:
(6*1)+(5*1)+(4*4)+(3*7)+(2*5)+(1*6)=64
64 % 10 = 4
So 1147-56-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8H,(H,14,16)/b15-12-
1147-56-4Relevant articles and documents
Formation of azolo [1,2,4]triazinium salts by reaction of heterocyclic-substituted 1-azo-naphthalen-2-ols with strong acids
Yu, Xiuling,Hartmann, Horst
, p. 501 - 508 (2014/06/10)
By reaction of heterocyclic-substituted 1-azo-naphth-2-ols with the Vilsmeier reagent or with strong acids polycyclic azolo[1,2,4]triazinium salts are formed in good yields. The azolo[1,2,4] triazinium salts exhibit similar UV/Vis absorption properties as the starting azo compounds, but in contrast to those the fluorescence appears in the visible range.
