114744-50-2

Basic information

• Product Name: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
• Synonyms: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE;5-bromo-1,2,3,4-tetrahydroquinoline;5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE1HCL SALT;5-bromo-1,2,3,4-tetrahydroquinoline HCl
• CAS NO: 114744-50-2
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 248.54734
• Mol File: 114744-50-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 300℃
• Flash Point: 135℃
• Appearance: /
• Density: 1.428
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.19±0.20(Predicted)
• CAS DataBase Reference: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE(114744-50-2)
• EPA Substance Registry System: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE(114744-50-2)

Safety Data

• Hazardous Substances Data: 114744-50-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-1,2,3,4-tetrahydro-quinoline hydrochloride is a chemical compound that is commonly used in research and development. It is a white crystalline powder with a molecular formula of C9H10BrN?HCl. 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE is often utilized as a building block in the synthesis of pharmaceuticals and other organic compounds. It is known for its diverse applications, including its use as an intermediate in the production of various drugs and as a reagent in chemical reactions. Additionally, it has been studied for its potential pharmacological properties and in the development of new medications. Overall, 5-Bromo-1,2,3,4-tetrahydro-quinoline hydrochloride is a versatile chemical with numerous potential uses in the field of organic chemistry and drug development.

InChI:InChI=1/C9H10BrN.ClH/c10-8-4-1-5-9-7(8)3-2-6-11-9;/h1,4-5,11H,2-3,6H2;1H

Upstream product

• 903557-27-7 4-bromo-1-indanone oxime 
• 4964-71-0 5-bromoquinoline 
• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 67-56-1 methanol 

Downstream Products

• 1622173-42-5 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone 

Relevant articles and documents

Ligand-Enabled Enantioselective Csp3 –H Activation of Tetrahydroquinolines and Saturated Aza-Heterocycles by RhI

The first rhodium(I)-catalyzed enantioselective intermolecular C (Formula presented.) –H activation of various saturated aza-heterocycles including tetrahydroquinolines, piperidines, piperazines, azetidines, pyrrolidines, and azepanes is presented. The combination of a rhodium(I) precatalyst and a chiral monodentate phosphonite ligand is shown to be a powerful catalytic system to access a variety of important enantio-enriched heterocycles from simple starting materials. Notably, the C (Formula presented.) –H activation of tetrahydroquinolines is especially challenging due to the adjacent C (Formula presented.) ?H bond. This redox-neutral methodology provides a new synthetic route to α-N-arylated heterocycles with high chemoselectivity and enantioselectivity up to 97 % ee.

Simple manganese carbonyl catalyzed hydrogenation of quinolines and imines

Manganese-catalyzed hydrogenation of unsaturated molecules has made tremendous progresses recently benefiting from non-innocent pincer or bidentate ligands for manganese. Herein, we describe the hydrogenation of quinolines and imines catalyzed by simple manganese carbonyls, Mn2(CO)10 or MnBr(CO)5, thus eliminating the prerequisite pincer-type or bidentate ligands.

Method for preparing tetrahydroquinoline compounds by catalytic hydrogenation of ruthenium catalyst

The invention relates to a method for preparing tetrahydroquinoline compounds by catalytic hydrogenation of a ruthenium catalyst, which comprises the following steps: by using p-cymene ruthenium chloride dimer as a catalyst and hydrogen as a reducing agent, mixing the p-cymene ruthenium chloride dimer, phosphine ligand and quinoline compounds, and dissolving the mixture in an organic solvent to react, and carrying out post-treatment to obtain the tetrahydroquinoline derivative. Compared with the prior art, the method has the advantages of easily available raw materials, mild conditions, simpleoperation, atom economy, simple and green synthesis process, mild reaction conditions, excellent selectivity, high yield and good reaction universality, and has a wide application value in fine chemical intermediate synthesis.

Method for selective catalytic hydrogenation of aromatic heterocyclic compounds in non-hydrogen participation manner

The invention discloses a method for selective catalytic hydrogenation of aromatic heterocyclic compounds in a non-hydrogen participation manner. The method comprises the following steps: by taking 1, 5-cyclooctadiene iridium chloride dimer as a catalyst and phenylsilane as a hydrogen source, carrying out stirring reaction under mild conditions without adding a ligand, namely catalytically hydrogenating the aromatic heterocyclic compounds to obtain hydrogenated products of the aromatic heterocyclic compounds. The method has the advantages of low cost, mild reaction conditions, high selectivity and the like, and special equipment such as a high-pressure kettle and the like and high-temperature conditions which are required when hydrogen is used are avoided.