1148025-82-4

Basic information

• Product Name: (E)-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-2-(4-tolyl)thioethene
• Synonyms: (E)-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-2-(4-tolyl)thioethene
• CAS NO: 1148025-82-4
• Molecular Weight: 465.659
• Mol File: 1148025-82-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-2-(4-tolyl)thioethene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-2-(4-tolyl)thioethene(1148025-82-4)
• EPA Substance Registry System: (E)-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-2-(4-tolyl)thioethene(1148025-82-4)

Safety Data

• Hazardous Substances Data: 1148025-82-4(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 875894-68-1 (Z)-1-(4-(methylphenyl)thio)-2-phenylstyrene 
• 194594-60-0 (4-(2-(dimethylamino)ethoxy)phenyl)boronic acid 
• 41424-40-2 (Z)-(1-phenylethene-1,2-diyl)bis(phenylsulfane) 
• 873078-93-4 N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethan-1-amine 
• 55805-32-8 (E)-1-bromo-1,2-diphenyl-2-(4-tolyl)thioethene 

Downstream Products

• 10540-29-1 tamoxifen 
• 10540-29-1 tamoxifen 

Relevant articles and documents

Nickel-Catalyzed Regioselective Cleavage of Csp2-S Bonds: Method for the Synthesis of Tri- and Tetrasubstituted Alkenes

We describe here an efficient route for the synthesis of (Z)-vinylic sulfides 3 via the highly regio- and stereoselective coupling of (Z)-1,2-bis(aryl(alkyl)thio)alkenes and Grignard reagents over a Ni catalyst under mild conditions. (Z)-Vinylic sulfides 3 are important intermediates in the synthesis of tri- and tetrasubstituted alkenes that are important construction blocks for drugs and natural products. The directing organosulfur groups (SR) can be converted to diaryl(alkyl) disulfides (RSSR) using H2O2 as oxidant, hence avoiding the waste of sulfur resources. The protocol provides a general method that is highly regio- and stereoselective for the synthesis of a diversity of tri- and tetrasubstituted alkenes.