114804-77-2

Basic information

• Product Name: 2-Naphthalenecarboxylic acid, 6-(phenylmethoxy)-
• CAS NO: 114804-77-2
• Molecular Formula: C18H14O3
• Molecular Weight: 278.307
• Mol File: 114804-77-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenecarboxylic acid, 6-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenecarboxylic acid, 6-(phenylmethoxy)-(114804-77-2)
• EPA Substance Registry System: 2-Naphthalenecarboxylic acid, 6-(phenylmethoxy)-(114804-77-2)

Safety Data

• Hazardous Substances Data: 114804-77-2(Hazardous Substances Data)

Upstream product

• 66217-29-6 6-(benzyloxy)-2-cyanonaphthalene 
• 16712-64-4 6-Hydroxy-2-naphthoic acid 
• 17295-11-3 methyl 6-hydroxynaphthalene-2-carboxylate 
• 114804-76-1 6-benzyloxynaphthalene-2-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 2234-45-9 6-benzyloxy-2-bromonaphthalene 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 124-38-9 carbon dioxide 
• 98256-93-0 6-Benzyloxy-naphthalene-2-carboxylic Acid Benzyl Ester 

Downstream Products

• 160535-03-5 (R)-1-(Trifluoromethyl)heptyl 6-benzyloxy-2-naphthoate 
• 187748-29-4 1'-methylethyl 2-benzyloxy-6-naphthoate 
• 114804-78-3 S(+)-1-Methylheptyl 6-benzyloxy-2-naphthoate 
• 1606979-39-8 C₃₆H₄₆O₃ 
• 122179-30-0 2-benzyloxynaphthalene-6-carboxylic acid chloride 
• 187748-44-3 2-n-butoxyethyl 2-benzyloxy-6-naphthoate 

Relevant articles and documents

6-benzyloxyimino-2-naphthoic acid manufacturing method (by machine translation)

PROBLEM TO BE SOLVED: reducing the formation of byproducts, high yield and purity by 6-benzyloxyimino-2-naphthoic acid. SOLUTION: 6-hydroxy-2-naphthoic acid, 6-benzyloxyimino-2-naphthoic acid benzylsuccinic (ester ether body) is generated, by hydrolysis,

Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors

A structure-activity relationship study for a series of vitamin D3-based (VD3) analogues that incorporate aromatic A-ring mimics with varying functionality has provided key insight into scaffold features that result in potent, selective Hedgehog (Hh) pathway inhibition. Three analogue subclasses containing (1) a single substitution at the ortho or para position of the aromatic A-ring, (2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the aromatic A-ring were prepared and evaluated. Aromatic A-ring mimics incorporating either single or multiple hydrophilic moieties on a six-membered ring inhibited the Hh pathway in both Hh-dependent mouse embryonic fibroblasts and cultured cancer cells (IC50 values 0.74-10 μM). Preliminary studies were conducted to probe the cellular mechanisms through which VD3 and 5, the most active analogue, inhibit Hh signaling. These studies suggested that the anti-Hh activity of VD3 is primarily attributed to the vitamin D receptor, whereas 5 affects Hh inhibition through a separate mechanism.

NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF

Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2). [wherein X is -CH2-, -O-, -S- or single bond; Ar is optionally substituted aryl or lower cycloalkyl; n is 0 to 2; R1 and R2 are (i) each is hydrogen or lower alkyl; (ii) R1 and R2 are combined to form lower alkylene; or (iii) R1 is hydrogen or lower alkyl and R2 is combined with R4 or R6 to form lower alkylene; R3 and R4 are (i) each is hydrogen or lower alkyl; (ii) R3 and R4 are combined to form lower alkylene; or (iii) R3 is hydrogen or lower alkyl and R4 is combined with R2 or R6 to form lower alkylene; R is or -OR7; R 5 and R6 are (i) each is optionally substituted lower alkyl, or hydrogen; (ii) R5 and R6 are combined to form aliphatic 5- to 6-membered heterocyclic group; or (iii) R5 is optionally substituted lower alkyl or hydrogen and R6 is combined with R2 or R4 to form lower alkylene; R7 is lower alkyl.