114871-40-8Relevant articles and documents
Synthesis of Oligoribonucleotides by Using 2'-O-(1-Methyl-1-methoxy)ethyl Nucleosides
Takaku, Hiroshi,Imai, Kazuaki,Nakayama, Koukichi
, p. 1787 - 1790 (2007/10/02)
3',5'-O-Tetraisopropyldisiloxanylnucleosides smoothly react with 2-methoxypropene to give 2'-O-(1-methyl-1-methoxy)ethyl nucleosides in high yields without formation of diastereoisomers.These nucleosides were used as intermediates for oligonucleotide synthesis by the phosphotriester method.The (1-methyl-1-methoxy)ethyl group was removed rapidly from oligonucleotides by acid treatment.