114898-40-7Relevant articles and documents
New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols
Eilertsen, Monica,Allin, Steve M.,Pearson, Russell J.
, p. 1106 - 1110 (2018/02/28)
S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.
Study of the Rh2(OAc)4- or BF3·OEt2-mediated reaction of thioacetic S-acid with α-diazocarbonyl compounds
Yao, Wengang,Liao, Mingyi,Zhang, Xiaomei,Xu, Hao,Wang, Jianbo
, p. 1784 - 1788 (2007/10/03)
The Rh2(OAc)4-catalyzed reaction of methyl aryldiazo-acetates with thioacetic S-acid gives exclusively the S-H insertion products in high yields, while the corresponding reaction mediated by BF3·OEt2 gives O-est
Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
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, (2008/06/13)
A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: STR1 wherein R1 and R2 are each a hydrogen atom, an C1 -C20 alkyl group, an C2 -C20 alkenyl group, an C2 -C20 alkynyl group, an aryl group, a C3 -C8 cycloalkyl group or an aralkyl group which may have a substituent, R3 is a hydrogen atom, an C1 -C20 alkyl group, an C2 -C20 alkenyl group, an C2 -C20 alkynyl group, a C3 -C8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.
