1149333-40-3

Basic information

• Product Name: tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
• Synonyms: 1,1-Dimethylethyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5h)-carboxylate;tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;1,6-Naphthyridine-6(5H)-carboxylic acid, 2-amino-7,8-dihydro-, 1,1-dimethylethyl ester
• CAS NO: 1149333-40-3
• Molecular Formula: C₁₃H₁₉N₃O₂
• Molecular Weight: 249.32
• Mol File: 1149333-40-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(1149333-40-3)
• EPA Substance Registry System: tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(1149333-40-3)

Safety Data

• Hazardous Substances Data: 1149333-40-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is a chemical compound with the molecular formula C15H21N3O2. It is a tert-butyl ester derivative of 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylic acid. tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate belongs to the class of naphthyridines, which are heterocyclic compounds containing a naphthyridine moiety, which consists of a naphthalene fused to a pyridine. Tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is used in chemical and pharmaceutical research as a building block and intermediate in organic synthesis. Its specific uses and potential applications are still being explored and studied.

Upstream product

• 1013-88-3 Benzophenone imine 
• 1149333-39-0 tert-butyl 2-(trifluoromethanesulfonyloxy)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 1151665-15-4 2-chloro-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 
• 1346673-94-6 tert-butyl 2-[(diphenylmethylidene)amino]-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 210539-05-2 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 766545-20-4 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 207691-65-4 N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine 
• 1036381-91-5 tert-butyl 2-hydroxy-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 

Downstream Products

• 1149333-50-5 1.1-dimethylethyl 2-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 
• 1149333-53-8 1,1-dimethylethyl 2-[({1-[(3,4-dichlorophenyl)methyl]-1H-pyrazol-4-yl}carbonyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS

Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Inhibiting effect of trisubstituted pyrimidine derivative on protein kinase

The invention discloses a trisubstituted pyrimidine derivative with a structure shown as general formula (I), and pharmaceutically acceptable salt, ester or solvent compound thereof. The derivative isa protein kinase inhibitor, can be used individually or in combination with other drugs for cancer treatment, and has tremendous clinical application value. General formula (I) is shown as the specification.

PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.