1149744-48-8

Basic information

• Product Name: ethyl (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoate
• Synonyms: ethyl (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoate
• CAS NO: 1149744-48-8
• Molecular Weight: 405.537
• Mol File: 1149744-48-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoate(1149744-48-8)
• EPA Substance Registry System: ethyl (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoate(1149744-48-8)

Safety Data

• Hazardous Substances Data: 1149744-48-8(Hazardous Substances Data)

Upstream product

• 1149744-45-5 4-hydroxymethyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)benzamide 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 209114-83-0 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-carbamoyl]benzaldehyde 
• 94497-53-7 methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-carbamoyl]benzoate 
• 94497-51-5 Am80 

Downstream Products

• 1020281-19-9 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid 
• 1149744-46-6 (2E)-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propenoic acid 
• 1417444-30-4 5-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]benzyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1417444-29-1 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionic acid-2,2-d₂ 
• 1489126-38-6 ethyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]propionate 

Relevant articles and documents

Synthesis of Am80 (tamibarotene) prodrug candidates, congeners and metabolites

Compound 1 (IT-M-07000) was previously reported as a candidate prodrug of Am80 (Tamibarotene; used to treat acute promyelocytic leukemia), and shown to be efficiently metabolized to Am80 via β-oxidation. Here, we describe in detail the synthesis of 1, together with another tetradeuterated candidate prodrug, IT-YA-00616 (2), as well as two congeners, and several metabolic intermediates of 1 previously detected in mouse plasma.