114977-29-6

Basic information

• Product Name: 2'-epi 3'-epi N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
• Synonyms: 2'-epi 3'-epi N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
• CAS NO: 114977-29-6
• Molecular Weight: 807.892
• Mol File: 114977-29-6.mol
• Article Data: 64

Chemical Properties

• CAS DataBase Reference: 2'-epi 3'-epi N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-epi 3'-epi N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol(114977-29-6)
• EPA Substance Registry System: 2'-epi 3'-epi N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol(114977-29-6)

Safety Data

• Hazardous Substances Data: 114977-29-6(Hazardous Substances Data)

Upstream product

• 195141-96-9 2'-(tert-butyldimethylsilyl)-7,10-di(triethylsilyl)docetaxel 
• 24424-99-5 di-tert-butyl dicarbonate 
• 133524-70-6 13-(O-2R-hydroxy-3S-amine-phenylpropionyl)-baccatin III 
• 114977-25-2 C₄₉H₅₅Cl₆NO₁₈ 
• 859498-34-3 (2*,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid 
• 32981-86-5 10-deacetylbaccatin III 
• 859498-33-2 (2*,4R,5S)-methyl N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-methionate 
• 202741-88-6 (4S,5R)-4-phenyl-2-trichloromethyl-1,3-oxazolidine-5-carboxylic acid 
• 155396-64-8 [(1S,2R)-2-Benzyloxy-3-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-oxo-1-phenyl-propyl]-carbamic acid tert-butyl ester 
• 155396-65-9 (2R,3S)-2-benzyloxy-3-tert-butoxy-carbonylamino-3-phenylpropanoic acid 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 150884-50-7 benzaldehyde N-boc imine 
• 100-52-7 benzaldehyde 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 144654-55-7 C₄₃H₅₃NO₁₄ 
• 262598-45-8 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel 
• 1068633-26-0 docetaxel/mono propylene glycol clathrate 
• 1568962-15-1 C₄₇H₆₃NO₁₄Si 
• 1568962-20-8 C₅₃H₇₅NO₁₄Si 

Relevant articles and documents

Improved protection and esterification of a precursor of the taxotere and taxol side chains

(4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected baccatins 9a,b. Smooth deprotection in formic acid gave the N-deprotected intermediates of Taxotere and taxol. This protocol did not generate any epimerization at C-2′ and constitutes a pratical method to prepare Taxotere, taxol and analogs.

Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes

A mixture of taxols was prepared from 10-deacetyl-7-xylosyltaxanes by three-step reactions: redox, acetylation, and deacetylation. The mixture was separated by column chromatography on silica gel to afford Taxol, Taxol B (Cephalomannine) and Taxol C. The mixture of Taxol B and Taxol C was converted to Docetaxel by Schwartz's reagent. The structures of Taxol and Docetaxel were characterized by HPLC, 1H-NMR, 13C-NMR and MS. This synthetic process has expanded the source of biomass for the chemical semi-synthesis of Taxol and Docetaxel, reduced the production costs, and increased the biomass resource of taxanes.

Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs

Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes. We s