114995-75-4Relevant articles and documents
Hydrostannylation-cross-coupling strategy for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters
Fujiwara, Shinichi,Cadou, Romain,Yamaoka, Yousuke,Takasu, Kiyosei,Yamada, Ken-Ichi
, p. 1264 - 1272 (2015/03/04)
A method for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters by a hydrostannylation-cross-coupling process has been developed. Pd-catalyzed and radical hydrostannylation of propiolate derivatives stereoselectively provided α-alkoxycarbonyl (E)- and (Z)-vinylstannanes, respectively, which were then converted into alkylidenemalonates by the Stille coupling reaction. A one-pot process was also realizable for the Pd-catalyzed reactions.