115-33-3 Usage
Description
Oxyphenisatine di(acetate) is a pro-drug of Oxyphenisatin (O876965), which is a compound with potential applications in the medical field. It has been found to inhibit the growth of breast cancer cell lines such as MCF7, T47D, HS578T, and MDA-MB-468.
Uses
1. Used in Anticancer Applications:
Oxyphenisatine di(acetate) is used as an anticancer agent for the inhibition of breast cancer cell lines. It has shown effectiveness in suppressing the growth of MCF7, T47D, HS578T, and MDA-MB-468 breast cancer cell lines, making it a promising candidate for further research and development in cancer treatment.
2. Used as a Laxative:
Oxyphenisatine di(acetate) is also used as a laxative to help relieve constipation. It is available under various brand names, including Isocrin (Parke-Davis), Lavema (Sterling Winthrop), Acelax, Acetalax, Alophen pills, Ameiax, Api-slender, Artzone, Belloform, Biivectan, Bisflatan, Boxogetten, Brocatine, Buta pirone, Buteril, Butofen, Butolfen, Bydolax, Chlofel, Chur-lax, Ciracen, Cirotex, Cirotyl, Contax, Critex, Curolax, Darmoletten, Deililax, Dialose plus, Diasatin, Ditnil, Ditmedol, Eulaxin, Evac-u-lax, Ex-lax pills, Febutolo, Fibutrox, Fim-a-mint, Fin-a-mint gum, Fisiolax, Flib 518, Inlax, Ipebutona, Isaaxan, Isaphenyn, Izaman, Laveman, Laxan-vomoxin, Laxaseptol, Laxem, Laxnormal, Laxocoleva, Laxon, Laxos, Laxyl, Med-laxan, Menabil complex, Muxol, Naleran, Neocervulax, Neo-favmadol, Neo-soldana, Nourilax, Nurilaksi, Obstilax, Otone, Oxybutazone, Phlogase, Phlogistol, Phlogont, Potsilo, Promassoletten, Prusol, Rheumapax, Rivolax, Schokilax, Syndian, Tanderil-alka, Tete-lax, and Validil.
Originator
Lavema,Winthrop,US,1959
Manufacturing Process
235 gravimetrical parts of acetic acid anhydride (90%) are poured over 106 gravimetrical parts of diphenolisatin (Berichte der Deutschen Chemischen Gesselschsft, 18, 1885, p. 2641) and the mixture is heated on the water-bath while stirring. The solid starting material temporarily dissolves almost entirely and shortly afterwards the reaction product turns into a crystalline paste. In order to complete the reaction the heating on the water-bath is continued for a short time and then the whole is left to get cold. The reaction product may, for instance, be separated in the following manner: To the cold reaction mixture is gradually added about the same volumetrical quantity of alcohol; in this manner the excess of acetic acid anhydride is destroyed and the paste becomes thinner. Then the fluid is drawn off and the product washed with alcohol. For complete cleansing another extraction is made with warm alcohol and the product crystallized, for instance, from 10 parts of acetic acid. The product represents a light, fine crystalline powder, which is difficultly soluble or even insoluble in the usual organic solvents. Its melting point lies at 242°C.
Therapeutic Function
Laxative
World Health Organization (WHO)
Oxyphenisatine acetate was widely used as a laxative after its
cathartic activity was first described in 1925. In 1969 its use was first associated
with cases of acute and chronic liver disease. This association is considered by
some, but not all, national drug regulatory authorities to warrant the withdrawal
from the market of preparations containing oxyphenisatine and its derivatives.
Check Digit Verification of cas no
The CAS Registry Mumber 115-33-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115-33:
(5*1)+(4*1)+(3*5)+(2*3)+(1*3)=33
33 % 10 = 3
So 115-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28)
