1150103-17-5

Basic information

• Product Name: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate
• Synonyms: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate
• CAS NO: 1150103-17-5
• Molecular Weight: 351.383
• Mol File: 1150103-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate(1150103-17-5)
• EPA Substance Registry System: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate(1150103-17-5)

Safety Data

• Hazardous Substances Data: 1150103-17-5(Hazardous Substances Data)

Upstream product

• 51767-39-6 4-(methylsulfonylamino)phenol 
• 188781-08-0 2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1150103-18-6 N-(4-{[5-(hydroxymethyl)-4-methyl-2-pyrimidinyl]oxy}phenyl)methanesulfonamide 
• 1150103-00-6 5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide 
• 1150103-19-7 N-{4-[(5-formyl-4-methyl-2-pyrimidinyl)oxy]phenyl}methanesulfonamide 

Relevant articles and documents

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

A novel series of pyridyl carboxamide-based CCR5 inhibitors was designed, synthesized, and demonstrated to be highly potent against HIV-1 infection in both HOS and PBL assays. Attempts to evaluate this series of compounds in a rat PK model revealed its instability in rat plasma. A hypothesis for this liability was proposed, and strategies to overcome this issue were pursued, leading to discovery of highly potent 40 and 41, which featured dramatically improved rat PK profiles. 2011 Elsevier Ltd. All rights reserved.