115015-98-0Relevant articles and documents
AN EFFICIENT ROUTE TO D-MYO-INOSITOL 1,3,4-TRIPHOSPHATE AND D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Gou, Da-Ming,Chen, Ching-Shih
, p. 721 - 724 (2007/10/02)
Multigram quantities of the title compounds in their enantiomerically-pure forms have been prepared by employing a chiral precursor which can be obtained via a facile enzymatic process.
The Total Synthesis of myo-Inositol Phosphates via myo-Inositol Orthoformate
Billington, David C.,Baker, Raymond,Kulagowski, Janusz J.,Mawer, Ian M.,Vacca, Joseph P.,et al.
, p. 1423 - 1429 (2007/10/02)
Novel selective alkylations of myo-inositol orthoformate (4) have been used to prepare a series of protected myo-inositol derivatives, (5a-e), (7), (10), (12), and (16).These intermediates have been used in efficient total syntheses of myo-inositol 2-phosphate, (9); myo-inositol 4-phosphate, (6); myo-inositol 1,3-bisphosphate, (18); and myo-inositol 1,3,4,5-tetrakisphosphate (14).This report represents the first total synthesis of the important natural metabolites (14) and (18) and significantly improved methods of preparation of (6) and (9).
TOTAL SYNTHESIS OF OPTICALLY ACTIVE MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Dreef, C. E.,Tuinman, R. J.,Elie, C. J. J.,Marel, G. A. van der,Boom, J. H. van
, p. 395 - 397 (2007/10/02)
A convenient approach to the preparation of the title compounds illustrating selective protection, optical resolution and phosphorylation is presented.