115019-43-7

Basic information

• Product Name: Toluene-4-sulfonic acid (S)-2-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptyl ester
• CAS NO: 115019-43-7
• Molecular Weight: 669.097
• Mol File: 115019-43-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (S)-2-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (S)-2-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptyl ester(115019-43-7)
• EPA Substance Registry System: Toluene-4-sulfonic acid (S)-2-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptyl ester(115019-43-7)

Safety Data

• Hazardous Substances Data: 115019-43-7(Hazardous Substances Data)

Upstream product

• 115019-36-8 (E)-ethyl 3β-(tert-buthyldimethylsiloxy)pregna-5,17-(20)-dien-21-oate 
• 42151-23-5 (3S)-3-tert-butyldimethylsilyloxyandrost-5-en-17-one 
• 115019-38-0 (20S)-ethyl 3β-(tert-butyldimethylsiloxy)-20-isocholesta-5,16-dien-21-oate 
• 98-59-9 p-toluenesulfonyl chloride 
• 115019-41-5 (S)-2-[(3S,8R,9S,10R,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-heptan-1-ol 

Relevant articles and documents

A New Stereoselective Synthesis of (20R)- and (20S)-Steroidal Side Chains

Reaction of (E)-ethyl 3β-t-butyldimethylsiloxypregna-5,17-dien-21-oate with lithium di-isopropylamide followed by alkyl halides results in the predominant formation of (20S)-alkylation products in >88percent isolated yields; a synthetic application to both (20R)- and (20S)-steroidal side chains is also described.