1150310-68-1

Basic information

• Product Name: levocetirizine N-benzyl amide
• Synonyms: levocetirizine N-benzyl amide
• CAS NO: 1150310-68-1
• Molecular Weight: 478.034
• Mol File: 1150310-68-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 45-49°C
• Boiling Point: 640.1±55.0 °C(Predicted)
• Density: 1.186±0.06 g/cm3(Predicted)
• CAS DataBase Reference: levocetirizine N-benzyl amide(CAS DataBase Reference)
• NIST Chemistry Reference: levocetirizine N-benzyl amide(1150310-68-1)
• EPA Substance Registry System: levocetirizine N-benzyl amide(1150310-68-1)

Safety Data

• Hazardous Substances Data: 1150310-68-1(Hazardous Substances Data)

Usage

Description

Levocetirizine N-benzyl amide is a chemical compound that serves as a reagent in the synthesis of pharmaceutical building blocks and alkaloid natural products. It plays a crucial role in the development of various medications and contributes to the advancement of pharmaceutical chemistry.

Uses

Used in Pharmaceutical Industry:
Levocetirizine N-benzyl amide is used as a reagent for the synthesis of pharmaceutical building blocks. It aids in the creation of essential components that form the foundation of various medications, enhancing the development and effectiveness of drugs.
Used in Alkaloid Natural Products Synthesis:
Levocetirizine N-benzyl amide is also utilized as a reagent in the synthesis of alkaloid natural products. Alkaloids are a diverse group of naturally occurring organic compounds that have significant biological activity. levocetirizine N-benzyl amide contributes to the production of alkaloids, which are used in the development of pharmaceuticals, particularly those with medicinal properties.

Upstream product

• 1150310-72-7 N-benzyl-2-(2-(bis(2-hydroxyethyl)amino)ethoxy)acetamide 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 100-46-9 benzylamine 
• 28022-43-7 p-chlorobenzhydrylamine 
• 1150310-73-8 N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide 
• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 

Downstream Products

• 130018-77-8 levocetirizine 

Relevant articles and documents

Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chemical industries. This challenge is highlighted by the estimate that 40-45% of drug candidates contain a chiral amine, fueling a demand for broadly applicable synthetic methods that deliver target structures in high yield and enantiomeric excess. Herein we describe the development and application of a "toolbox" of monoamine oxidase variants from Aspergillus niger (MAO-N) which display remarkable substrate scope and tolerance for sterically demanding motifs, including a new variant, which exhibits high activity and enantioselectivity toward substrates containing the aminodiphenylmethane (benzhydrylamine) template. By combining rational structure-guided engineering with high-throughput screening, it has been possible to expand the substrate scope of MAO-N to accommodate amine substrates containing bulky aryl substituents. These engineered MAO-N biocatalysts have been applied in deracemization reactions for the efficient asymmetric synthesis of the generic active pharmaceutical ingredients Solifenacin and Levocetirizine as well as the natural products (R)-coniine, (R)-eleagnine, and (R)-leptaflorine. We also report a novel MAO-N mediated asymmetric oxidative Pictet-Spengler approach to the synthesis of (R)-harmicine.